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3.4.25.1: proteasome endopeptidase complex

This is an abbreviated version!
For detailed information about proteasome endopeptidase complex, go to the full flat file.

Word Map on EC 3.4.25.1

Reaction

cleavage of peptide bonds with very broad specificity =

Synonyms

20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.22.21, EC 3.4.24.5, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, proteasome subunit alpha-type 7-like, PSMA5, Psma8, RING12 protein, RN3, Scl1, SCL1 suppressor protein, SFRICE_003436, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.25 Threonine endopeptidases
                3.4.25.1 proteasome endopeptidase complex

Source Tissue

Source Tissue on EC 3.4.25.1 - proteasome endopeptidase complex

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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primary cells, and cell lines
Manually annotated by BRENDA team
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immortalized with Epstein Barr virus
Manually annotated by BRENDA team
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primary Waldenstroem macroglobulinemia cells
Manually annotated by BRENDA team
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localization in nuclei of neurons of the putamen and substantia nigra of Parkinson's disease patients, no nuclear localization is observed in the same areas of brains of controls
Manually annotated by BRENDA team
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trypsin-like, the chymotrypsin-like, and the peptidyl-glutamyl peptide hydrolase activity of the 20S proteasome increase distinctly from freshly hatched larvae to pre-molt Z1. During the Z2 stage, the activities are highest in the post-molt animals, decrease in the inter-molt animals, and increase again in the pre-molt animals. A similar but less distinct trend is evident in the Z3 stages. In the juveniles, the proteasomal activities decrease toward the lowest values. A similar pattern is present for the chymotrypsin-like activity of the 26S proteasome
Manually annotated by BRENDA team
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colon cancer cell line
Manually annotated by BRENDA team
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prostate cancer cell line
Manually annotated by BRENDA team
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prostate cancer cell line
Manually annotated by BRENDA team
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a C57BL/6-derived methylcholantrene-induced fibrosarcoma cell line
Manually annotated by BRENDA team
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multiple myeloma cell
Manually annotated by BRENDA team
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multiple myeloma cell
Manually annotated by BRENDA team
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primary, multiple
Manually annotated by BRENDA team
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neuroblastoma cell line
Manually annotated by BRENDA team
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pheochromocytoma cells
Manually annotated by BRENDA team
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prostate cancer cell line
Manually annotated by BRENDA team
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after germination, northern blot analysis
Manually annotated by BRENDA team
subunit PSMA8-associated proteasomes are essential for the degradation of meiotic proteins and the progression of meiosis I during spermatogenesis
Manually annotated by BRENDA team
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localization in nuclei of neurons of the putamen and substantia nigra of Parkinson's disease patients, no nuclear localization is observed in the same areas of brains of controls
Manually annotated by BRENDA team
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osteosarcoma cell line
Manually annotated by BRENDA team
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from subjects with Alexander disease, significantly decreased PGPH and chymotrypsin-like protease activities in white matter from Alexander disease patients expressing GFAP R239C, R416W, and R239H mutants
Manually annotated by BRENDA team
additional information