3.4.25.1: proteasome endopeptidase complex
This is an abbreviated version!
For detailed information about proteasome endopeptidase complex, go to the full flat file.
Word Map on EC 3.4.25.1
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3.4.25.1
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bortezomib
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myeloma
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polyubiquitinated
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neurodegenerative
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misfolded
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lysosomal
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histone
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chymotrypsin-like
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ligases
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leukemia
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relapsed
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nf-kappab
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immunomodulatory
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parkinsonism
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lymphoma
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deacetylase
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ubiquitin-dependent
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alzheimer
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cyclins
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hematologic
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caspase
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histocompatibility
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proteostasis
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ubiquitin-like
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dexamethasone
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hsp90
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deubiquitinating
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ubiquitin-conjugating
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calpains
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autologous
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inclusions
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incurable
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cyclin-dependent
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short-lived
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mantle
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trypsin-like
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progression-free
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thalidomide
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ubiquitin-mediated
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polyglutamine
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ikappab
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mcl-1
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multisubunit
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mdm2
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ikappabalpha
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parkin
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rituximab
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alpha-synuclein
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single-agent
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p27kip1
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synthesis
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medicine
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degradation
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analysis
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drug development
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biotechnology
- 3.4.25.1
- bortezomib
- myeloma
-
polyubiquitinated
- neurodegenerative
-
misfolded
- lysosomal
- histone
-
chymotrypsin-like
- ligases
- leukemia
-
relapsed
- nf-kappab
-
immunomodulatory
- parkinsonism
- lymphoma
- deacetylase
-
ubiquitin-dependent
- alzheimer
- cyclins
- hematologic
-
caspase
-
histocompatibility
-
proteostasis
-
ubiquitin-like
- dexamethasone
- hsp90
-
deubiquitinating
-
ubiquitin-conjugating
- calpains
-
autologous
- inclusions
-
incurable
-
cyclin-dependent
-
short-lived
-
mantle
-
trypsin-like
-
progression-free
- thalidomide
-
ubiquitin-mediated
-
polyglutamine
- ikappab
- mcl-1
-
multisubunit
- mdm2
- ikappabalpha
- parkin
- rituximab
- alpha-synuclein
-
single-agent
- p27kip1
- synthesis
- medicine
- degradation
- analysis
- drug development
- biotechnology
Reaction
cleavage of peptide bonds with very broad specificity =
Synonyms
20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.22.21, EC 3.4.24.5, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, proteasome subunit alpha-type 7-like, PSMA5, Psma8, RING12 protein, RN3, Scl1, SCL1 suppressor protein, SFRICE_003436, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3
ECTree
3.4.25.1 proteasome endopeptidase complexAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.25.1 - proteasome endopeptidase complex
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dihydrofolate reductase + H2O
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directly hydrolyzed by the 20S complex, without any previous ubiquitination. The degradation is increased under oxidative conditions. The folate metabolism may be impaired by an increased degradation of dihydrofolate reductase, mediated by the 20S proteasome
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PS1/gamma-secretase complex component + H2O
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gamma-secretase components are PS1, nicastrin, Pen-2, and Aph-1. Degradation of the complex components involves the proteasome, but regulation of their activity involves the PI3K/Akt pathway, overview. PS1/gamma-secretase is involved in the activation of phosphatidylinositol-3 kinase/Akt pathway, and is responsible for the intramembranous cleavage of various type-I membrane proteins. PS1/gamma-secretase is also deeply involved in the production of amyloid beta protein
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additional information
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several other proteins associate with the Arabidopsis thaliana proteasome, including the PBAC2 assembly chaperonin, the associated DSS1/Sem1/RPN15 protein, the deubiquitylating enzyme UBP16, and the alternative activator PA200, genetic analysis of PA200 in Arabidopsis, overview
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additional information
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several other proteins associate with the Arabidopsis thaliana proteasome, including the PBAC2 assembly chaperonin, the associated DSS1/Sem1/RPN15 protein, the deubiquitylating enzyme UBP16, and the alternative activator PA200, genetic analysis of PA200 in Arabidopsis, overview
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additional information
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the tobacco mosaic virus-induced RNP7 subunit may be involved in programmed cell death
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additional information
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proteasome status in KG1a and U937 cells, overview
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additional information
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three major proteolytic activities of the proteasome can be distinguished as trypsin-like, chymotrypsin-like, and peptidyl-glutamyl peptide hydrolase activities, which cleave peptide bonds on the carboxyl side of basic, hydrophobic, and acidic amino acid residues, respectively. The catalytic core of the 20S proteasome is a Thr residue, responsible for the catalytic cleavage of substrates through nucleophilic attack
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additional information
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proteasomes are the primary sites for protein degradation in mammalian cells. Each proteasome particle contains two chymotrypsin-like, two trypsin-like, and two caspase-like proteolytic sites
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additional information
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the chymotrypsin-like and trypsin-like activities, but not the peptidylglutamyl peptide hydrolyzing activity plays a key role in oocyte maturation
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additional information
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the proteasome is a cylindrical, multicatalytic proteolytic machine with three peptidase activities, chymotryptic, tryptic and postglutamyl peptide hydrolytic
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additional information
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mass spectrometric analysis of proteasome interactions. Several proteasome-interacting proteins unique to synaptic 26S proteasomes, i.e. 14-3-3gamma, TAX1BP1, drebrin, SNAP-25, may modulate proteolysis in a synapse-specific manner. Three E3s, i.e. KCMF1, HUWE1, and UBE3A, and five DUBs, i.e. USP5, USP7, USP13, USP14, and UCH37, in association with synaptic proteasomes, which may help proteasomes function more efficiently, help determine specificity for certain types of conjugates, or insure the rapid elimination of ubiquitin chains released from the substrate
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additional information
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mass spectrometric analysis of proteasome interactions. Several proteasome-interacting proteins unique to synaptic 26S proteasomes, i.e. 14-3-3gamma, TAX1BP1, drebrin, SNAP-25, may modulate proteolysis in a synapse-specific manner. Three E3s, i.e. KCMF1, HUWE1, and UBE3A, and five DUBs, i.e. USP5, USP7, USP13, USP14, and UCH37, in association with synaptic proteasomes, which may help proteasomes function more efficiently, help determine specificity for certain types of conjugates, or insure the rapid elimination of ubiquitin chains released from the substrate
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