3.4.25.1: proteasome endopeptidase complex

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For detailed information about proteasome endopeptidase complex, go to the full flat file.

Word Map on EC 3.4.25.1

3.4.25.1

bortezomib

myeloma

polyubiquitinated

neurodegenerative

misfolded

lysosomal

histone

chymotrypsin-like

ligases

leukemia

relapsed

nf-kappab

immunomodulatory

parkinsonism

lymphoma

deacetylase

ubiquitin-dependent

alzheimer

cyclins

hematologic

caspase

histocompatibility

proteostasis

ubiquitin-like

dexamethasone

hsp90

deubiquitinating

ubiquitin-conjugating

calpains

autologous

inclusions

incurable

cyclin-dependent

short-lived

mantle

trypsin-like

progression-free

thalidomide

ubiquitin-mediated

polyglutamine

ikappab

mcl-1

multisubunit

mdm2

ikappabalpha

parkin

rituximab

alpha-synuclein

single-agent

p27kip1

synthesis

medicine

degradation

analysis

drug development

biotechnology

Reaction

cleavage of peptide bonds with very broad specificity =

Synonyms

20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.22.21, EC 3.4.24.5, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, proteasome subunit alpha-type 7-like, PSMA5, Psma8, RING12 protein, RN3, Scl1, SCL1 suppressor protein, SFRICE_003436, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.25 Threonine endopeptidases

3.4.25.1 proteasome endopeptidase complex

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Results	in table
29	Activating Compound
12975	AA Sequence
14	Application
1	CAS Registry Number
17	Cloned(Commentary)
8	Cofactor
19	Crystallization (Commentary)
25550	Disease/ Diagnostics
4	Expression
50	General Information
2	General Stability
77	IC50 Value
316	Inhibitors
7	kcat/KM [mM/s]
18	Ki Value [mM]
33	KM Value [mM]
21	Localization
21	Metals/Ions
59	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
556	Organism
11829	PDB ID
40	pH Optimum
22	pI Value
5	Posttranslational Modification
5	Protein Variants
48	Purification (Commentary)
13	Reaction
1	Reaction Type
229	Reference
1	Renatured (Commentary)
199	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
267	Substrates and Products (Substrate)
36	Subunits
187	Synonyms
35	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
33	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 3.4.25.1 - proteasome endopeptidase complex

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Ca2+

5 entries

Cd2+

Solanum lycopersicum

0.3 mM Cd2+ lead to a 1.6 and 2.3fold increase in the 20S proteasome activity after 3 and 10 days, respectively, in leaves, the chymotrypsin activity of the 20S proteasome is maximally increased only after 3 days of treatment with 0.03 mM and 0.3 mM Cd2+ (1.5 and 2.5fold, respectively), no major effect of Cd2+ on the chymotrypsin activity of the 20S proteasome is observed in roots or leaves of plant treated with low Cd2+ concentrations (0.0003 mM and 0.003 mM)

689687

Cl-

Methanosarcina thermophila

stimulates chymotrypsin-like activity

137329

K+

2 entries

Mg2+

7 entries

Mn2+

Methanosarcina thermophila

stimulates chymotrypsin-like activity

137329

Na+

Rattus norvegicus

100 mM, decreases the rate of hydrolysis of succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin and succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin 2fold

670038

PMSF

Struthio camelus

activates chymotrypsin-like activity

137351

Zn2+

2 entries