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3.4.25.1: proteasome endopeptidase complex

This is an abbreviated version!
For detailed information about proteasome endopeptidase complex, go to the full flat file.

Word Map on EC 3.4.25.1

Reaction

cleavage of peptide bonds with very broad specificity =

Synonyms

20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.22.21, EC 3.4.24.5, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, proteasome subunit alpha-type 7-like, PSMA5, Psma8, RING12 protein, RN3, Scl1, SCL1 suppressor protein, SFRICE_003436, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.25 Threonine endopeptidases
                3.4.25.1 proteasome endopeptidase complex

Cloned

Cloned on EC 3.4.25.1 - proteasome endopeptidase complex

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
26S proteasome subunits phylogenetic analysis
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cloning of the alpha-type subunit of the 20S catalytic core
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expressed in 293 cell line
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expressed in Escherichia coli
expressed in Escherichia coli BL21 (DE3) cells and AH109 cells
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expressed in Escherichia coli BL21(DE3) cells
expressed in Hep-G2 cells
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expressed in Jurkat cells
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expressed in MDA-MB-231 breast cancer cells
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expressed in Saccharomyces cerevisiae
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expression in Escherichia coli
PSMA5 is subcloned into the vector pET-22b(+) and expressed as inclusion bodies in Escherichia coli BL21
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the similarity of the derived amino acid sequences of 233 (alpha subunit) and 211 (beta subunit) residues, respectively, indicates that they arose from a common ancestral gene. The alpha-subunits have regulatory and targeting functions, while the beta-subunits carry the active sites