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3.4.25.1: proteasome endopeptidase complex

This is an abbreviated version!
For detailed information about proteasome endopeptidase complex, go to the full flat file.

Word Map on EC 3.4.25.1

Reaction

cleavage of peptide bonds with very broad specificity =

Synonyms

20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.22.21, EC 3.4.24.5, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, proteasome subunit alpha-type 7-like, PSMA5, Psma8, RING12 protein, RN3, Scl1, SCL1 suppressor protein, SFRICE_003436, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.25 Threonine endopeptidases
                3.4.25.1 proteasome endopeptidase complex

Application

Application on EC 3.4.25.1 - proteasome endopeptidase complex

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
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simultaneous labeling and detection of constitutive 20S proteasome subunits using an affinity-based probe cocktail and application to biological samples
biotechnology
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the 20S proteasome could be an as yet not identified bottleneck in the expression and secretion of some heterologous proteins by Streptomyces lividans. Optimization of the production of specific heterologous proteins is likely to require engineered Streptomyces lividans strains, in which the proteasome has been removed
degradation
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targeted proteasomal knockdown of GFP is induced by use of a specific anti-GFP nanobody in plants. GFP is depleted by a chimeric nanobody fused to a distinct F-box domain, which enables protein degradation via the ubiquitin proteasome pathway
drug development
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the proteasome is a target for inhibitor development and optimization, overview
medicine
synthesis
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the incorporation of parus subunits into Arabidopsis holoprotease raises the intriguing possibility that plants synthesize multiple 26S proteasome types with unique properties and/or target specificities
additional information
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peptide splicing is an intrinsic additional catalytic property of the proteasome, which may provide a qualitative peptide pool for immune selection