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3.4.24.B8: ADAM1 endopeptidase

This is an abbreviated version!
For detailed information about ADAM1 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B8

Reaction

proteolytic degradation of proteins =

Synonyms

a disintegrin and metalloprotease 1, a disintegrin and metalloproteinase domain 1, a disintegrin and metalloproteinase domain 1a, a disintegrin and metalloproteinase domain 1b, ADAM 1, ADAM 1a, ADAM 1b, ADAM-1, ADAM1, ADAM1a, ADAM1b, fertilin, fertilin alpha, fertilin alpha 1a subunit, fertilin alpha 1b subunit, fertilin alpha subunit, M12.201, PH-30

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B8 ADAM1 endopeptidase

Metals Ions

Metals Ions on EC 3.4.24.B8 - ADAM1 endopeptidase

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
activates, required
Mg2+
-
activates
Mn2+
-
activates
Zn2+
metalloprotease domain in the beta subunit precursor region, but not in the mature protein, the alpha-subunit conatins a metalloprotease domain, which is the active site, in the mature from with the consensus sequence HEXXHXXGXXHE
additional information
-
divalent cations are required for membrane fusion