3.4.24.B5: matrix metalloproteinase-15

This is an abbreviated version!
For detailed information about matrix metalloproteinase-15, go to the full flat file.

Word Map on EC 3.4.24.B5

3.4.24.B5

metalloproteinases

mmp-2

metastasis

gelatinase

mt3-mmp

zymography

timp-1

gelatin

prommp-2

basement

progelatinase

pericellular

gelatinolytic

mt1-mmp-mediated

emmprin

diagnostics

medicine

Reaction

proteolytic degradation of proteins =

Synonyms

M10.015, matrix metalloproteinase 15, membrane type 2 matrix metalloproteinase, membrane type 2-Mmp, membrane-type matrix metalloproteinase, membrane-type matrix metalloproteinase 2, membrane-type-1 matrix metalloproteinase, membrane-type-2 matrix metalloproteinase, membrane-type-3 matrix metalloproteinase, MMP-15, MMP15, MT MMP, MT-MMP 2, MT1 MMP, MT2 MMP, MT2-MMP, Mt2-mmp/Mmp15, MT2MMP, MT3 MMP, MTMMP2, SMCP-2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.B5 matrix metalloproteinase-15

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Results	in table
5	Activating Compound
4	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
717	Disease/ Diagnostics
5	Expression
6	General Information
6	Inhibitors
9	Localization
3	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
16	Organism
2	pH Optimum
2	Protein Variants
1	Purification (Commentary)
1	Reaction
5	Reaction Type
16	Reference
57	Source Tissue
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
1	Subunits
54	Synonyms
2	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 3.4.24.B5 - matrix metalloproteinase-15

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(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-Ala-Arg-NH2 + H2O

Homo sapiens

synthetic fluorogenic substrate

651039

cell surface tissue transglutaminase + H2O

4 major and several minor cleavage products of cell surface tissue transglutaminase

Homo sapiens

P50281

at the leading edge of motile cancer cells, membrane-type-1, -type -2 and -type-3 matrix metalloproteases

652122

cell surface tissue transglutaminase + H2O

Homo sapiens

P50281

regulation of cancer cell adhesion, degradation supresses specifically cell adhesion and migration on fibronectin, but stimulates migration of cells on collagen

652122

matrix metalloproteinase progelatinase A + H2O

matrix metalloproteinase gelatinase A

Homo sapiens

substrate is activated by cleavage

651039

pro-form of matrix metalloproteinase 2 + H2O

active form of matrix metalloproteinase 2

Homo sapiens

MMP-2 hemopexin carboxyl domain-dependent activation process

680683

progelatinase A + H2O

gelatinase A + ?

3 entries

protein + H2O

peptides

6 entries

Type I collagen + H2O

Homo sapiens

weak collagenase activity

680683

additional information

Homo sapiens

P51511

the enzyme does not cleave endoglin

735055