Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.24.B5: matrix metalloproteinase-15

This is an abbreviated version!
For detailed information about matrix metalloproteinase-15, go to the full flat file.

Word Map on EC 3.4.24.B5

Reaction

proteolytic degradation of proteins =

Synonyms

M10.015, matrix metalloproteinase 15, membrane type 2 matrix metalloproteinase, membrane type 2-Mmp, membrane-type matrix metalloproteinase, membrane-type matrix metalloproteinase 2, membrane-type-1 matrix metalloproteinase, membrane-type-2 matrix metalloproteinase, membrane-type-3 matrix metalloproteinase, MMP-15, MMP15, MT MMP, MT-MMP 2, MT1 MMP, MT2 MMP, MT2-MMP, Mt2-mmp/Mmp15, MT2MMP, MT3 MMP, MTMMP2, SMCP-2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B5 matrix metalloproteinase-15

Source Tissue

Source Tissue on EC 3.4.24.B5 - matrix metalloproteinase-15

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
high expression of MMP-15 in tumour samples
Manually annotated by BRENDA team
peripheral
Manually annotated by BRENDA team
-
trends in expression of MMP-15 is similar between brain and spinal cord samples
Manually annotated by BRENDA team
of the ovarian follicles
Manually annotated by BRENDA team
-
cancer cell line, low expression of MT2 MMP
Manually annotated by BRENDA team
-
squamous carcinoma cell line, expresssion of MT2 MMP not MT1 MMP and MT3 MMP
Manually annotated by BRENDA team
-
squamous carcinoma cell line, expresssion of MT2 MMP not MT1 MMP and MT3 MMP
Manually annotated by BRENDA team
overexpression of MMP-15 in human lung adenocarcinoma compared with normal lung
Manually annotated by BRENDA team
-
small expression
Manually annotated by BRENDA team
-
MMP-15 is expressed at a significantly higher level by myeloid cells than by T cells
Manually annotated by BRENDA team
has lowest MMP-15 expression of all cell lines
Manually annotated by BRENDA team
-
MMP-15 is mainly expressed by resting microglia, and this is reduced 15fold in experimental autoimmune encephalomyelitis
Manually annotated by BRENDA team
MMP15 is overexpressed in acute myeloid leukemia (AML) patients
Manually annotated by BRENDA team
-
MMP-15 expression is significantly lower in tumor tissue compared with normal tissue
Manually annotated by BRENDA team
-
MMP-15 message is down-regulated 5.5fold in experimental autoimmune encephalomyelitis
Manually annotated by BRENDA team
-
in tumour tissues MMP-15 is expressed at a significantly higher level in stroma tissue when compared to tissue fromt the epithelially derived compartment
Manually annotated by BRENDA team
-
cancer cell line, low expression of MT2 MMP
Manually annotated by BRENDA team
-
cancer cell line, low expression of MT2 MMP
Manually annotated by BRENDA team
primary human trophoblasts from 50 first trimester placentas (gestational week 7-12), high MMP115 expression
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
-
cancer cell line, low expression of MT2 MMP and expression of MT3 MMP
Manually annotated by BRENDA team
additional information