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3.4.24.B5: matrix metalloproteinase-15

This is an abbreviated version!
For detailed information about matrix metalloproteinase-15, go to the full flat file.

Word Map on EC 3.4.24.B5

Reaction

proteolytic degradation of proteins =

Synonyms

M10.015, matrix metalloproteinase 15, membrane type 2 matrix metalloproteinase, membrane type 2-Mmp, membrane-type matrix metalloproteinase, membrane-type matrix metalloproteinase 2, membrane-type-1 matrix metalloproteinase, membrane-type-2 matrix metalloproteinase, membrane-type-3 matrix metalloproteinase, MMP-15, MMP15, MT MMP, MT-MMP 2, MT1 MMP, MT2 MMP, MT2-MMP, Mt2-mmp/Mmp15, MT2MMP, MT3 MMP, MTMMP2, SMCP-2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B5 matrix metalloproteinase-15

Expression

Expression on EC 3.4.24.B5 - matrix metalloproteinase-15

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after phosphorylation (by CDK9 and cyclin 1), Pgr becomes a functional transcription factor for mmp15 gene expression
endothelin-1 (ET-1) downregulates matrix metalloproteinase 15 expression in human first trimester trophoblasts via endothelin receptor type B (ETRB). ET-1 downregulates MMP15 mRNA and protein levels. TNF-alpha enhances ET-1-mediated MMP15 downregulation in primary trophoblasts
inhibition of follicle ovulation, by the inhibitors roscovitine or CDK9-inhibitor II, is accompanied by the suppression of Mmp15 expression in the follicle. Roscovitine treatment of follicles inhibits Pgr binding to the mmp15 promoter region
Mmp15 is an luteinizing hormone (LH)-inducible enzyme
the enzyme is significantly up-regulated in placentas from severe early-onset preeclamptic pregnancies compared to gestationally matched preterm controls