3.4.24.B5: matrix metalloproteinase-15
This is an abbreviated version!
For detailed information about matrix metalloproteinase-15, go to the full flat file.
Word Map on EC 3.4.24.B5
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3.4.24.B5
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metalloproteinases
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mmp-2
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metastasis
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gelatinase
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mt3-mmp
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zymography
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timp-1
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gelatin
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prommp-2
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basement
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progelatinase
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pericellular
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gelatinolytic
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mt1-mmp-mediated
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emmprin
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diagnostics
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medicine
- 3.4.24.B5
- metalloproteinases
- mmp-2
- metastasis
- gelatinase
-
mt3-mmp
-
zymography
- timp-1
- gelatin
- prommp-2
-
basement
- progelatinase
-
pericellular
-
gelatinolytic
-
mt1-mmp-mediated
-
emmprin
- diagnostics
- medicine
Reaction
proteolytic degradation of proteins =
Synonyms
M10.015, matrix metalloproteinase 15, membrane type 2 matrix metalloproteinase, membrane type 2-Mmp, membrane-type matrix metalloproteinase, membrane-type matrix metalloproteinase 2, membrane-type-1 matrix metalloproteinase, membrane-type-2 matrix metalloproteinase, membrane-type-3 matrix metalloproteinase, MMP-15, MMP15, MT MMP, MT-MMP 2, MT1 MMP, MT2 MMP, MT2-MMP, Mt2-mmp/Mmp15, MT2MMP, MT3 MMP, MTMMP2, SMCP-2
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Expression
Expression on EC 3.4.24.B5 - matrix metalloproteinase-15
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after phosphorylation (by CDK9 and cyclin 1), Pgr becomes a functional transcription factor for mmp15 gene expression
endothelin-1 (ET-1) downregulates matrix metalloproteinase 15 expression in human first trimester trophoblasts via endothelin receptor type B (ETRB). ET-1 downregulates MMP15 mRNA and protein levels. TNF-alpha enhances ET-1-mediated MMP15 downregulation in primary trophoblasts
inhibition of follicle ovulation, by the inhibitors roscovitine or CDK9-inhibitor II, is accompanied by the suppression of Mmp15 expression in the follicle. Roscovitine treatment of follicles inhibits Pgr binding to the mmp15 promoter region
the enzyme is significantly up-regulated in placentas from severe early-onset preeclamptic pregnancies compared to gestationally matched preterm controls