3.4.24.B5: matrix metalloproteinase-15

This is an abbreviated version!
For detailed information about matrix metalloproteinase-15, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M10.015, matrix metalloproteinase 15, membrane type 2 matrix metalloproteinase, membrane type 2-Mmp, membrane-type matrix metalloproteinase, membrane-type matrix metalloproteinase 2, membrane-type-1 matrix metalloproteinase, membrane-type-2 matrix metalloproteinase, membrane-type-3 matrix metalloproteinase, MMP-15, MMP15, MT MMP, MT-MMP 2, MT1 MMP, MT2 MMP, MT2-MMP, Mt2-mmp/Mmp15, MT2MMP, MT3 MMP, MTMMP2, SMCP-2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B5 matrix metalloproteinase-15

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5	Activating Compound
4	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
717	Disease/ Diagnostics
5	Expression
6	General Information
6	Inhibitors
9	Localization
3	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
16	Organism
2	pH Optimum
2	Protein Variants
1	Purification (Commentary)
1	Reaction
5	Reaction Type
16	Reference
57	Source Tissue
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
1	Subunits
54	Synonyms
2	Temperature Optimum [°C]

Cloned

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Cloned on EC 3.4.24.B5 - matrix metalloproteinase-15

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

cloned into pcDNA 3.1/myc-His and subcloned into pLXSN to yield myc-His-tagged MMP-15

Homo sapiens

P51511

669385

expressed in Escherichia coli and in Timp2-/- skin fibroblasts

Homo sapiens

-

680683

expression of the enzymes catalytic domain in Escherichia coli

Homo sapiens

-

651039

functional expression of enzyme in HT1080 cells and U251 glioma cells, leading to enhanced levels of pro-matrix metalloprotease-2

Homo sapiens

P50281

652122

gene MMP15, quantitative expression analysis

Homo sapiens

P51511

754240

gene MMP15, quantitative RT-PCR enzyme expression analysis

Homo sapiens

P51511

753776

gene mmp15, reverse transcription and real-time PCR expression analysis

Oryzias latipes

H2MKS4

753226