3.4.24.B4: matrix metalloproteinase-13
This is an abbreviated version!
For detailed information about matrix metalloproteinase-13, go to the full flat file.
Word Map on EC 3.4.24.B4
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3.4.24.B4
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cartilage
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chondrocytes
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osteoarthritis
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metalloproteinases
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joint
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articular
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aggrecan
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degeneration
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mmp-2
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tnf
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knee
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timp-1
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arthritis
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synovial
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interleukin-1
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proteoglycans
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degener
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cox-2
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osteoblast
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adamts-5
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ligament
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intra-articular
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collagenases
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col2a1
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thrombospondin
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pulposus
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runx2
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cruciate
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zymography
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chondrogenic
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gelatinase
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meniscus
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intervertebral
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subchondral
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disintegrin
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endochondral
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safranin
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synoviocytes
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collagenolytic
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matrix-degrading
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chondroprotective
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ossification
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temporomandibular
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mt1-mmp
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chondrogenesis
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medicine
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stromelysin-1
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diagnostics
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cartilage-specific
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condylar
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analysis
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osteophyte
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drug development
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aggrecanase
- 3.4.24.B4
- cartilage
- chondrocytes
- osteoarthritis
- metalloproteinases
- joint
-
articular
- aggrecan
- degeneration
- mmp-2
- tnf
- knee
- timp-1
- arthritis
- synovial
- interleukin-1
- proteoglycans
-
degener
- cox-2
- osteoblast
- adamts-5
- ligament
-
intra-articular
- collagenases
-
col2a1
- thrombospondin
- pulposus
- runx2
-
cruciate
-
zymography
-
chondrogenic
- gelatinase
- meniscus
-
intervertebral
-
subchondral
-
disintegrin
-
endochondral
-
safranin
- synoviocytes
-
collagenolytic
-
matrix-degrading
-
chondroprotective
-
ossification
-
temporomandibular
- mt1-mmp
-
chondrogenesis
- medicine
- stromelysin-1
- diagnostics
-
cartilage-specific
-
condylar
- analysis
- osteophyte
- drug development
- aggrecanase
Reaction
proteolytic degradation of proteins =
Synonyms
collagenase, collagenase 3, collagenase-3, M10.013, matrix metalloproteinase 13, matrix metalloproteinase-13, MMP-13, MMP13, MMP13a, More, UMRCASE
ECTree
3.4.24.B4 matrix metalloproteinase-13Advanced search results
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results (Source Tissue
Source Tissue on EC 3.4.24.B4 - matrix metalloproteinase-13
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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healthy and elastase-perfused aortas. Increased MMP-13 in experimental abdominal aortic aneurysms in males compared with females, while there are no differences in aortic diameter, collagen, and MMP-13 levels in baseline males versus females, MMP-13 expression analysis, overview
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myoblast cell line, expression of enzyme and tissue inhibitor of matrix metalloproteinase, TIMP-1, is regulated by Wnt signaling combined with bone morphogenic protein BMP-2 in osteoblastic differentiation
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MMP-13 is the only enzyme whose induction and expression coincides with the onset of angiogenesis and blood vessel formation. MMP-13-positive cells appear shortly after angiogenic stimulation and then accumulate in the collagen onplant tissue. Morphologically, the chMMP-13-containing cells appear as hematopoietic cells of monocyte/macrophage lineage
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from maxillary and mandibular jaws, semi-quantitative RT-PCR analysis, overview
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expression of MMP-13 increases following the gonadotropin surge. MMP-13 is localized to granulosal and thecal layers
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from keratocyst odontogenic tumours, stromal tissue and mesenchymal cells, distribution of MMP-13 expression, overview
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MMP-13 expression in the tissues around in vivo developing oral sulcus at E11, 12, and 13, immunohistochemic analysis
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MMP-13 is mainly produced by neurons, but also by oligodendrocytes
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MMP-13 in perivascular cells may be involved in removal of cartilage matrix proteins such as type II collagen and aggrecan
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expression of MMP13 in the synovial membrane of patients with rheumatoid and osteoarthritis
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high expression of MMP13 in rheumatoid arthritis synovial tissue
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nearly all chondrocyte-like cells are immunopositive, whereas fibroblast-like cells and fibrochondrocytes are more rarely labelled
additional information
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enzyme is expressed during both intramembranous ossification in skull and endochondral ossification in long bones during gestation
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subchondral bone, mRNA expressions of matrix metalloproteinase-13 is significantly enhanced in osteoarthritis subchondral bone osteoblasts compared to subchondral bone osteoblasts without osteoarthritis. The expression of these gene is greater in patients with severe cartilage damage than in those with mild cartilage damage
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mRNA encoding MMP13 is present in multiple cell types involved in human fetal bone development
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MMP13 is expressed by hypertrophic chondrocytes and osteoblasts in the fracture callus
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surfaces under the ruffled borders and some clear zones of osteoclasts. MMP-13 may play an important role in the degradation of type I collagen in bone matrix, acting in concert with cathepsin K and MMP-9 produced by osteoclasts
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upregulation of active MMP-13 in rat brains after 90 min of cerebral ischemia
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upregulation of active MMP-13 in rat brains after 90 min of cerebral ischemia
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femoral condyles and tibial plateaus, preferential expression of MMP-13 in the deep zone
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obtained from patients with rheumatoid arthritis and osteoarthritis. CCAAT/enhancer binding protein beta, i.e. C/EBPbeta, and MMP-13 expressions are colocalized in chondrocytes in arthritic cartilage
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healthy and osteoarthritic, MMP-13 RT-PCR expression analysis, overview
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expression by fibroblasts inadult gingival and in fetal skin wounds characterized by rapid collagen remodeling and scarless healing
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during experimental gastric ulcer healing induced by acetic acid injection MMP-3 and MMP-3 expression is increased in stromal cells of the gastric mucosa bordering the ulcer. MMP-13 RNAs are confined to the upper layers of the granulation tissue
MMP-13 is the principal proteinase expressed by the mesenchymal stromal cells of giant cell tumor
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from healthy subjects, patients with gingivitis, and with periodontitis, immunohistochemic analysis, overview
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scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13
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MMP-13 is mainly produced by neurons, but also by oligodendrocytes
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arthritic, from osteoarthritis and rheumatoid arthritis patients, the level of MMP-13 is higher in rheumatoid arthritis than in osteoarthritis samples. MMP-13 levels are highly associated with vascular endothelial growth factor levels in both osteoarthritis and rheumatoid arthritis fluids
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from healthy persons and rheumatoid arthritis patients, the latter show a higher MMP-13 level
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epithelial-myoepithelial, immunohistochemic determination of MMP-13 and other MMPs, overview. The overall level of MMP-13 is low, thereby the average indices of MMP-13 in epithelial cells are higher than in myoepithelial cells
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expression by fibroblasts in adult gingival and in fetal skin wounds characterized by rapid collagen remodeling and scarless healing
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MMP-13 expression is negligible in the normal unwounded skin at day 0, but it increases on days 1 to 7 upon wounding, diminishes on day 14 and disappears on day 28
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high levels of MMP13 mRNA only in malignant squamous epithelium of the skin, while premalignant and benign tumors are mostly negative for MMP13
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enzyme expression is related to tumor aggresiveness
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induced tumors, stromal MMP13 is associated with vascular endothelial growth factor receptor-2 on endothelial cells in invasive areas. Tumour invasion was downregulated in Mmp13-/- animals. Kinetics of angiogenesis and tumour growth in surface transplants, overview
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from healthy persons and rheumatoid arthritis patients, the latter show a higher MMP-13 level
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interleukin-1beta-stimulated rheumatoid arthritis fibroblast-like, semi-quantitative RTPCR MMP-13 expression analysis
additional information
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MMP-13 is expressed in osteoarthritis and rheumatoid arthritis patients, but not in normal adult tissues
additional information
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MMP-13 quantitative real-time PCR expression analysis, overview
additional information
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no MMP-13 expression in THP-1 cells, HL-60 cells, and Jurkat cells
additional information
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the levels of MMP-13 in gingival crevicular fluid samples are not influenced by diabetes mellitus type 2, overview
additional information
MMP-13 pattern of expression in various healthy tissues and during embryogenesis, MMP-13 expression is slightly increased in the first day post-fertilization and sharply up-regulated from 1-day postfertilization through hatching, quantitative RT-PCR analysis, overview
additional information
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MMP-13 pattern of expression in various healthy tissues and during embryogenesis, MMP-13 expression is slightly increased in the first day post-fertilization and sharply up-regulated from 1-day postfertilization through hatching, quantitative RT-PCR analysis, overview
additional information
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expression analysis of MMP13 in healthy and wounded skin, overview
additional information
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MMP-13 mRNA abundance is greatly enhanced in Hdac4-deficient mice compared with wild-type or heterozygous littermates. MMP-13 staining in the tibiae of knockout mice is strongly detected in late hypertrophic chondrocytes and bone regions compared with wild-type or heterozygous mice
additional information
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Mmp13 is expressed in mouse choroidal neovascular lesions induced by laser burn
additional information
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MMP13 is upregulated at the breast tumor-bone interface, gene expression profiling, overview
additional information
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Mmp13 is expressed in mouse choroidal neovascular lesions induced by laser burn
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additional information
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osteoblastic osteosarcoma cell line UMR 106-01, Ca2+-dependent binding in a two-step mechanism via the required specific enzyme receptor and LDL-receptor-related protein, internalization and degradation of the enzyme, also binding to fibroblastic cells
additional information
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ibuprofen upregulates expressions of MMP-13 both at mRNA and protein levels
