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3.4.24.B4: matrix metalloproteinase-13

This is an abbreviated version!
For detailed information about matrix metalloproteinase-13, go to the full flat file.

Word Map on EC 3.4.24.B4

Reaction

proteolytic degradation of proteins =

Synonyms

collagenase, collagenase 3, collagenase-3, M10.013, matrix metalloproteinase 13, matrix metalloproteinase-13, MMP-13, MMP13, MMP13a, More, UMRCASE

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B4 matrix metalloproteinase-13

Activating Compound

Activating Compound on EC 3.4.24.B4 - matrix metalloproteinase-13

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12-O-tetradecanoyl phorbol 13-acetate
-
8fold activation of transcriptional activity in chondrocytes
amino phenylmercuric acetate
-
activation
angiotensin II
-
-
hepatocyte growth factor
-
stimulation of enzyme expression in osteoarthritic chondrocytes
-
integrins
-
e.g. integrin alpha1beta and alpha2beta1, induction via MAPkinase
-
interleukin-1
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alpha and beta form, induction of enzyme expression, which is inhibited by 15-deoxy-DELTA12,14-prostaglandin J2, induction of enzyme expression in chondrosarcoma cells requires nuclear factor-kappaB nuclear translocation, p38 MAPkinase activity, c-Jun N-terminal kinase activity
-
interleukin-1alpha
-
10 ng/ml
-
interleukin-1beta
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activates, hyaluronan inhibits interleukin-1beta-stimulated MMP-13 via CD44 in arthritic chondrocytes
-
oncostatin
-
induction of enzyme expression, requires phosphorylation of JAK3
-
p-aminophenylmercuric acetate
-
purified proMMP-13 is activated using 1 mM amino phenyl mercuric acid for 20 h at 35°C
Smad
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indirect stimulation via regulation of transforming growth factor-beta responsive genes
-
stromelysin-1
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concentration-dependent activation by cleavage of the proform
-
transforming growth factor-beta
-
enhances MMP-13 expression
-
transforming growth factor-beta1
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strong induction of enzyme expression in KMST fibroblasts, increase of enzyme expression by inhibition of p38 mitose-activated protein kinase
-
Tumor necrosis factor alpha
-
induction of enzyme expression, which is inhibited by 15-deoxy-DELTA12,14-prostaglandin J2
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additional information
-