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3.4.24.B37: mutalysin II

This is an abbreviated version!
For detailed information about mutalysin II, go to the full flat file.

Word Map on EC 3.4.24.B37

Reaction

The enzyme cleaves the Ala14-/-Leu15 bond of insulin B-chain very rapidly and the Phe24-/-Phe25, His10-/-Leu11 and His5-/-Leu6 bonds additional information slowly =

Synonyms

haemorrhagic factor 2, hemorrhagic factor II, LHF-II, LHFII, snake venom metalloproteinase hemorrhagic factor 2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B37 mutalysin II

Substrates Products

Substrates Products on EC 3.4.24.B37 - mutalysin II

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-Pro-Leu-Gly-Leu-Leu-Gly-Arg-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Pro-Leu-Gly-Leu + Leu-Gly-Arg-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
?
Bovine insulin B-chain + H2O
?
show the reaction diagram
the enzyme cleaves the Ala14-/-Leu15 bond of insulin B-chain very rapidly and the Phe24-/-Phe25, His10-/-Leu11 and His5-/-Leu6 bonds more slowly
-
-
?
casein + H2O
?
show the reaction diagram
-
-
-
?
Dimethylcasein + H2O
?
show the reaction diagram
Fibrin + H2O
?
show the reaction diagram
-
-
-
?
fibrinogen alpha-chain + H2O
?
show the reaction diagram
the enzyme hydrolyzes selectively the alpha-chain of fibrinogen, leaving the beta- and gamma-chains unaffected
-
-
?
human fibrin + H2O
?
show the reaction diagram
-
-
-
?
human fibrinogen alpha-chain + H2O
?
show the reaction diagram
-
-
-
?
murine fibrin + H2O
?
show the reaction diagram
-
-
-
?