3.4.24.B28: ADAM15

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For detailed information about ADAM15, go to the full flat file.

Reaction

proteolysis of proteins =

Synonyms

a disintegrin and metalloproteinase 15, ADAM15 endopeptidase, ADAM15 isoforms i1, ADAM15 isoforms i2, ADAM15 isoforms i3, ADAM15 isoforms i4, ADAM15 isoforms i5, ADAM15 isoforms i6

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B28 ADAM15

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Results	in table
2	AA Sequence
2	Application
3	Cloned(Commentary)
431	Disease/ Diagnostics
5	Expression
13	General Information
4	Inhibitors
3	kcat/KM [mM/s]
3	KM Value [mM]
11	Localization
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
16	Organism
1	Posttranslational Modification
1	Purification (Commentary)
1	Reaction
16	Reference
27	Source Tissue
8	Substrates and Products (Substrate)
5	Subunits
10	Synonyms
3	Turnover Number [1/s]

Expression

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Expression on EC 3.4.24.B28 - ADAM15

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

ADAM15 expression is down-regulated in melanoma metastasis compared to primary melanoma. Interferon-gamma and tumor growth factor-beta1 down-regulate ADAM15 protein levels in melanoma cells

Homo sapiens

-

718739

ADAM15 mRNA is up to 4fold upregulated when endothelial cells are exposed to physiologic shear stress

Homo sapiens

Q13444

754444

enzyme expression is increased in pancreatic cancer cells compared to normal pancreatic tissue

Homo sapiens

Q13444

734701

severe hypoxia persistently up-regulates ADAM15 mRNA and protein levels in hippocampus and neocortex but not in thalamus or hypothalamus

Rattus norvegicus

-

720555

the enzyme is up-regulated in the rheumatoid arthritis synovial membrane

Homo sapiens

Q13444

733230