3.4.24.B27: ADAM19

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For detailed information about ADAM19, go to the full flat file.

Reaction

proteolysis of proteins =

Synonyms

ADAM19, ADAM19 endopeptidase, adamalysin19, disintegrin and metalloproteinase domain-containing protein 19

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B27 ADAM19

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Results	in table
2	AA Sequence
1	Cloned(Commentary)
174	Disease/ Diagnostics
2	Expression
3	General Information
1	Localization
2	Natural Substrates/ Products (Substrates)
5	Organism
1	Protein Variants
1	Reaction
5	Reference
2	Source Tissue
2	Substrates and Products (Substrate)
4	Synonyms

Source Tissue

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Source Tissue on EC 3.4.24.B27 - ADAM19

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

choriocarcinoma cell

Homo sapiens

-

in choriocarcinoma cell line JEG-3, the overexpression of ADAM19 leads to diminished cell invasion, as well as increases in cell adhesiveness and the expression of E-cadherin, with no changes in beta-catenin expression

710558

brenda

placenta

Homo sapiens

-

ADAM19 is widely distributed in villous cytotrophoblast cells, syncytiotrophoblast cells, column trophoblasts, and villous capillary endothelial cells during early pregnancy. The mRNA and protein level of ADAM19 in placentas is high at gestational weeks 8-9, but diminishes significantly at mid- and term pregnancy

710558

brenda