3.4.24.B26: myroilysin

This is an abbreviated version, for detailed information about myroilysin, go to the full flat file.

Reaction

broad specificity, elastinolytic activity and collagen-swelling ability =

Synonyms

M10.064, More

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B26 myroilysin

Substrates Products

Substrates Products on EC 3.4.24.B26 - myroilysin

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
bovine elastin + H2O
?
show the reaction diagram
casein + H2O
?
show the reaction diagram
Collagen + H2O
?
show the reaction diagram
Elastin + H2O
?
show the reaction diagram
the enzyme shows much higher elastinolytic activity than the bacterial elastinase pseudolysin (EC 3.4.24.26). It has 6.78 U/mg elastinolytic activity in artificial seawater at 4C, suggesting that it probably can degrade elastin in the deep sea
-
-
?
elastinorcein + H2O
?
show the reaction diagram
-
-
-
?
Fibrin + H2O
?
show the reaction diagram
hydrolyzes alpha, beta and gamma fibrin. Cleavage sites on fibrinogen and fibrin are different from those of pseudolysin
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
Gelatin + H2O
?
show the reaction diagram
-
-
-
?
Insulin B-chain + H2O
?
show the reaction diagram
N-succinyl-Ala-Ala-Ala-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + p-nitroaniline
show the reaction diagram
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline
show the reaction diagram
-
-
-
?
N-succinyl-Phe-Ala-Ala-Phe-p-nitroanilide + H2O
N-succinyl-Phe-Ala-Ala-Phe + p-nitroaniline
show the reaction diagram
-
-
-
?
additional information
?
-