3.4.24.B23: stage IV sporulation protein FB
This is an abbreviated version!
For detailed information about stage IV sporulation protein FB, go to the full flat file.
Reaction
implicated in the coupling of mother cell to forespore gene expression. Required for spore formation. Processes the pro-sigma K factor =
Synonyms
More, pro-sigmaK protease, SPOIVFB, SpoIVFB protein
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 3.4.24.B23 - stage IV sporulation protein FB
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
additional information
?
-
-
regulation of SpoIVFB activity is achieved by a proteolytic cascade involving serine proteases, which are used as S1P protease in other S2P cascades. SpoIVB and CtpB are not involved in Site-1 cleavage of substrate but are required to relieve the inhibition of SpoIVFB by SpoIVFA and BofA
-
-
?
sigmaK + peptide
-
involved in the sporulation process
-
-
?
pro-sigmaK + H2O
sigmaK + peptide
-
involved in the sporulation process
-
-
?
pro-sigmaK + H2O
sigmaK + peptide
-
involved in the sporulation process
-
-
?
pro-sigmaK + H2O
sigmaK + sigmaK propeptide
-
maturation and activation of sigmaK by proteolytic removal of an N-terminal extension of 20 amino acids. Pro-sigmaK is associated with the outer forespore membrane with its N-terminal transmembrane segment, amino acids 1 to 27. Proteolytic cleavage by SpoIVFB releases the C-terminal sigmaK into the mother cell for directing transcription of genes involved in spore cortex and coat synthesis
-
-
?
pro-sigmaK + H2O
sigmaK + sigmaK propeptide
-
SpoIVFB protein and SpoIVFB protein with an extra transmembrane segment cleave membrane-tethered pro-sigmaK, releasing sigmaK to direct transcription of genes necessary for spore formation. The CBS domain of SpoIVFB interacts with pro-sugmaK, and ATP changes the interaction, suggesting that ATP regulates substrate access to the active site and renders cleavage sensitive to the cellular energy level
-
-
?
pro-sigmaK + H2O
sigmaK + sigmaK propeptide
-
cleavage site between S20 and Y21
-
-
?