3.4.24.B20: FtsH protease

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For detailed information about FtsH protease, go to the full flat file.

Reaction

degradative cleavage of proteins =

Synonyms

AAA protease, AtFtsH, AtFtsH2, AtFtsH5, AtFtsH6, ATP-dependent zinc metalloprotease, filamentation temperature sensitive H, filamentation temperature sensitive H protease, FtsH, FtsH (slr0228), FtsH metalloprotease, FtsH protease, FtsH protease slr0228, FtsH1, FtsH10, FtsH11, FtsH12, FtsH2, FtsH2 protease, FtsH3, FtsH4, FtsH5, FtsH6, FtsH7, FtsH8, FtsH9, FTSHA, FtsHB, HflB, M41.005, More, putative cell division protein, RISP-degrading activity, slr0228, VAR1, VAR2, zinc dependent protease, ZmFtsH2A, ZmFtsH2B

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B20 FtsH protease

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Results	in table
16	Activating Compound
24	AA Sequence
1	CAS Registry Number
20	Cloned(Commentary)
27	Cofactor
3	Crystallization (Commentary)
7	Expression
65	General Information
2	General Stability
13	Inhibitors
106	Localization
38	Metals/Ions
40	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
315	Organism
3	pH Optimum
17	pI Value
2	Posttranslational Modification
30	Protein Variants
10	Purification (Commentary)
2	Reaction
9	Reaction Type
116	Reference
33	Source Tissue
104	Substrates and Products (Substrate)
51	Subunits
167	Synonyms
4	Temperature Optimum [°C]

Crystallization

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of the Enzyme Summary Page.

Crystallization on EC 3.4.24.B20 - FtsH protease

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

structures of a transmembrane helix-lacking FtsH construct from Aquifex aeolicus, at 2.9 A and 3.3 A resolution in space groups R32 and P312, respectively. In both structures, the FtsH hexamer is created from two different subunits of the asymmetric unit by the threefold symmetry of the crystals. All subunits are loaded with ADP. Within the ATPase cycle while the whole subunit switches from the opened to the closed state, pore loop-1 interacts with the substrate and translocates it into the proteolytic chamber

Aquifex aeolicus

O67077

754502

vapor diffusion method, using either 2 M ammonium sulfate, 0.1 M Tris-HCl pH 8.5, 10 mM EDTA or, as another condition, 60% tacsimate pH 7.0, 10 mM adenylyl imidodiphosphate lithium salt hydrate

Aquifex aeolicus

O67077

733011

cytosolic region of apo-FtsH, microbatch method by mixing equal volumes of 20 mg/ml protein with crystallization buffer containing 30% w/v PEG 400, 200 mM CaCl2, 100 mM HEPES, pH 7.5, 200 mM glycine, and 0.1-0.2% w/v low-melt agarose, 20°C, X-ray diffraction structure determination and analysis at 2.6 A resolution

Thermotoga maritima

Q9WZ49

713403