3.4.24.B18: m-AAA protease
This is an abbreviated version!
For detailed information about m-AAA protease, go to the full flat file.
Word Map on EC 3.4.24.B18
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3.4.24.B18
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paraplegia
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hereditary
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ataxia
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spinocerebellar
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atpases
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oma1
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proteostasis
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cristae
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dynamin-like
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homo-oligomeric
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paraparesis
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spastin
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hetero-oligomeric
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inner-membrane
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medicine
- 3.4.24.B18
- paraplegia
- hereditary
- ataxia
- spinocerebellar
- atpases
- oma1
-
proteostasis
-
cristae
-
dynamin-like
-
homo-oligomeric
- paraparesis
- spastin
-
hetero-oligomeric
-
inner-membrane
- medicine
Reaction
proteolytic degradation of proteins =
Synonyms
AAA protease, AFG3-like protein 2, Afg3l1, AFG3L2, ClpX, lon protease, m-AAA protease, m-AAA+ protease, M41.003, mitochondrial AAA protease, mitochondrial AAA+ protein, mitochondrial ATPase associated with various activities protease, mitochondrial mAAA protease, mitochondrial respiratory chain complexes assembly protein RCA1, paraplegin, SCRG_02514, SPG7, TAT-binding homolog 12, Yme1L, Yta10, Yta12, YTA12p
ECTree
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Reaction
Reaction on EC 3.4.24.B18 - m-AAA protease
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proteolytic degradation of proteins
conserved metal-binding site HEXXH, selective degradation, mechanism
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proteolytic degradation of proteins
degradation of hydrophobic membrane-spanning segments of misfolded mitochondrial membrane proteins
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proteolytic degradation of proteins
enzyme shows overlapping substrate specificity with the ATP-dependent PIM1 protease located in the mitochondrial matrix
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proteolytic degradation of proteins
m-AAA protease shows overlapping substrate specificity with the i-AAA protease, enzyme degrades domains of substrate proteins exposed to the opposite membrane surface, active site contains the conserved motif HEXXH, a helical region is located at the extreme C-terminus of the subunit
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proteolytic degradation of proteins
mechanism, m-AAA protease shows overlapping substrate specificity with the i-AAA protease, intermolecular catalytic role of SRH domain at the C-terminus of the AAA domain, m-AAA protease shows overlapping substrate specificity with the i-AAA protease, enzyme degrades domains of substrate proteins exposed to the opposite membrane surface, active site contains the conserved motif HEXXH, a helical region is located at the extreme C-terminus of the subunit
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proteolytic degradation of proteins
mechanism, model, degradation of hydrophobic membrane-spanning segments of misfolded mitochodrial membrane proteins
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proteolytic degradation of proteins
overlapping substrate specificity with i-AAA protease EC 3.4.24.B19, mechanism, reaction involves an active extraction of transmembrane segments and transport of solvent-exposed domains across the membrane, inner membrane proteins, active site at the opposite membrane surface
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