3.4.24.B18: m-AAA protease

This is an abbreviated version!
For detailed information about m-AAA protease, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

AAA protease, AFG3-like protein 2, Afg3l1, AFG3L2, ClpX, lon protease, m-AAA protease, m-AAA+ protease, M41.003, mitochondrial AAA protease, mitochondrial AAA+ protein, mitochondrial ATPase associated with various activities protease, mitochondrial mAAA protease, mitochondrial respiratory chain complexes assembly protein RCA1, paraplegin, SCRG_02514, SPG7, TAT-binding homolog 12, Yme1L, Yta10, Yta12, YTA12p

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B18 m-AAA protease

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Results	in table
7	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
13	Cofactor
3	Crystallization (Commentary)
354	Disease/ Diagnostics
25	General Information
1	IC50 Value
4	Inhibitors
52	Localization
4	Metals/Ions
1	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
85	Organism
37	Protein Variants
7	Purification (Commentary)
8	Reaction
7	Reaction Type
49	Reference
15	Source Tissue
64	Substrates and Products (Substrate)
21	Subunits
69	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]

Inhibitors

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Inhibitors on EC 3.4.24.B18 - m-AAA protease

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

bortezomib

Homo sapiens

-

-

734690

MG132

Homo sapiens

-

-

734690

prohibitin

Saccharomyces cerevisiae

-

located at the periphery of mitochondria at protein import sites, has a regulatory role, deletion of prohibitin leads to accelerated degradation of non-assembled membrane proteins by the m-AAA protease, overexpression of prohibitin stabilizes non-native polypeptides against degradation

649814

-

additional information

Homo sapiens

-

not inhibited by epoxomicin

734690

-