3.4.24.B18: m-AAA protease

This is an abbreviated version!
For detailed information about m-AAA protease, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

AAA protease, AFG3-like protein 2, Afg3l1, AFG3L2, ClpX, lon protease, m-AAA protease, m-AAA+ protease, M41.003, mitochondrial AAA protease, mitochondrial AAA+ protein, mitochondrial ATPase associated with various activities protease, mitochondrial mAAA protease, mitochondrial respiratory chain complexes assembly protein RCA1, paraplegin, SCRG_02514, SPG7, TAT-binding homolog 12, Yme1L, Yta10, Yta12, YTA12p

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B18 m-AAA protease

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
7	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
13	Cofactor
3	Crystallization (Commentary)
354	Disease/ Diagnostics
25	General Information
1	IC50 Value
4	Inhibitors
52	Localization
4	Metals/Ions
1	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
85	Organism
37	Protein Variants
7	Purification (Commentary)
8	Reaction
7	Reaction Type
49	Reference
15	Source Tissue
64	Substrates and Products (Substrate)
21	Subunits
69	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]

Cofactor

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Cofactor on EC 3.4.24.B18 - m-AAA protease

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Cofactor Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

ATP

9 entries

additional information

Mus musculus

-

metalloprotease complex

711611

-

ATP

Homo sapiens

-

-

732470, 734573

ATP

Saccharomyces cerevisiae

-

-

719994

ATP

Homo sapiens

-

required

734690

ATP

Saccharomyces cerevisiae

-

dependent on

650958, 653198, 719365

ATP

eukaryota

-

ATP binding is required for enzyme assembly, enzyme contains conserved Walker-type ATPase domain of approximately 230 amino acids, dependent on

649814

ATP

Saccharomyces cerevisiae

-

ATP binding is required for enzyme assembly, enzyme contains conserved Walker-type ATPase domain of approximately 230 amino acids, dependent on

649814

ATP

Saccharomyces cerevisiae

-

dependent on, enzyme contains an ATPase domain with a Walker-type P-loop typical for the AAA protease family

650372

ATP

Saccharomyces cerevisiae

-

dependent on, enzyme contains an ATPase domain with a Walker-type P-loop typical for the AAA protease family, hydrolysis induces conformational changes of the AAA domain driving substrate unfolding and dislocation from the membrane

649814

ATP

Saccharomyces cerevisiae

-

intersubunit coordination of the ATP hydrolysis leads to an ordered ATP hydrolysis within the AAA ring, which ensures efficient substrate dislocation from the membrane and translocation to the proteolytic chamber

718997