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3.4.24.B17: FtsH endopeptidase

This is an abbreviated version!
For detailed information about FtsH endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B17

Reaction

proteolytic degradation of proteins =

Synonyms

cell division protein ftsH, FtsH, FtsH protease, FTSH_ECOLI, HflB, HlB, M41.001, MtFtsH, T.ftsH

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B17 FtsH endopeptidase

Substrates Products

Substrates Products on EC 3.4.24.B17 - FtsH endopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-deoxy-D-manno-octulosonate transferase + H2O
?
show the reaction diagram
3-deoxy-D-manno-octulosonate transferase carries out the attachment of two KDO residues to the lipid A precursor (lipid IVA) to form the minimal essential structure of the lipopolysaccharide (KDO2-lipid A). Thus, FtsH regulates the concentration of the lipid moiety of LPS (lipid A) as well as the sugar moiety (KDO-based core oligosaccharides), ensuring a balanced synthesis of lipopolysaccharide
-
-
?
alpha-casein + H2O
?
show the reaction diagram
apo-flavodoxin + H2O
?
show the reaction diagram
-
degradation of apo-flavodoxin from Escherichia coli, no degradation of holo-flavodoxin containing non-covalently bound flavin mononucleotide. A mutant flavodoxin carrying a substitution of Tyr94 to Asp (FldYD) with a lower affinity for FMN is efficiently degraded. FtsH is able to initiate degradation of the FldYD moiety even when it is sandwiched by glutathione S-transferase, green fluorescent protein, or both green fluorescent protein and glutathione S-transferase
-
-
?
ATP + H2O
?
show the reaction diagram
bacteriophage lambdaCII repressor protein + H2O
?
show the reaction diagram
-
-
-
-
?
barnase tagged with SsrA tail + H2O
?
show the reaction diagram
-
tail specific degradation
-
?
beta-casein + H2O
?
show the reaction diagram
beta-casein + H2O
small peptides of 13-20 amino acid residues
show the reaction diagram
-
-
product analysis
?
biotin carboxylase/biotin carboxyl carrier protein + H2O
?
show the reaction diagram
-
-
-
-
?
BODIPY-casein + H2O
?
show the reaction diagram
-
-
-
?
casein + H2O
?
show the reaction diagram
casein + H2O
peptides
show the reaction diagram
-
-
-
?
chimeric protein PhoA-TM8-C30 + H2O
?
show the reaction diagram
-
recombinant substrate protein consists of one transmembrane segment of protein SecY, i.e. TM8, plus the following 30 residues of a cytoplasmic part, and the C-terminal end of alkaline phosphatase PhoA
-
?
CII protein of phage lambda + H2O
?
show the reaction diagram
-
-
-
?
colicin D + H2O
?
show the reaction diagram
colicin E3 + H2O
?
show the reaction diagram
conserved hypothetical protein NCgl1985 + H2O
?
show the reaction diagram
-
-
-
-
?
CTP + H2O
?
show the reaction diagram
-
-
-
-
?
dihydrofolate reductase tagged with SsrA tail + H2O
?
show the reaction diagram
-
tail specific degradation
-
?
doxorubicin resistance protein B + H2O
?
show the reaction diagram
F0a protein + H2O
?
show the reaction diagram
F0a subunit of the ATP synthetase + H2O
?
show the reaction diagram
-
-
-
-
?
FeoB protein + H2O
?
show the reaction diagram
-
-
-
-
?
FGH-(NO2)FFAF-methyl ester + H2O
FGH-(NO2)F + Phe-Ala-Phe-methyl ester
show the reaction diagram
-
exclusively cleaved at the (NO2)Phe-Phe bond
-
?
flavodoxin + H2O
?
show the reaction diagram
FtsZ protein + H2O
?
show the reaction diagram
-
-
-
-
?
fusion protein SecY-(P5)-PhoA + H2O
?
show the reaction diagram
-
recombinant substrate protein consists of one protein SecY without its C-terminus, and the alkaline phosphatase PhoA
-
?
glutamate binding protein + H2O
?
show the reaction diagram
-
-
-
-
?
glyceraldehyde-3-phosphate dehydrogenase + H2O
?
show the reaction diagram
-
-
-
-
?
GTP + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock sigma factor RpoH (sigma32) + H2O
?
show the reaction diagram
in addition to the turnover element in region 2.1, a second region important for proteolysis of RpoH by FtsH lies in region C of the sigma factor
-
-
?
heat shock transcription factor sigma32 protein + H2O
?
show the reaction diagram
-
-
-
-
?
homocysteine methyltransferase + H2O
?
show the reaction diagram
-
-
-
-
?
isocitrate lyase + H2O
?
show the reaction diagram
-
-
-
-
?
lambda protein CII + H2O
?
show the reaction diagram
-
cytoplasmic regulatory protein
-
?
lambda Xis + H2O
?
show the reaction diagram
-
protein substrate is required for site-specific excision of phage lambda from the bacterial chromosome
-
?
largely unfolded alpha-lactalbumin + H2O
peptides
show the reaction diagram
no activity with the native protein, cleavage of small peptides from the C-terminal side of hydrophobic residues, no large intermediates
between 10 and 30 kDa, no large intermediates
?
LpxC + H2O
?
show the reaction diagram
LpxC protein + H2O
?
show the reaction diagram
malate synthase + H2O
?
show the reaction diagram
-
-
-
-
?
MgtC mutant W226A
?
show the reaction diagram
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
phage lambda CII protein + H2O
small peptides
show the reaction diagram
-
enzyme participates in the phage lambda lysis-lysogeny decision by degrading the CII transcriptional activator and by its response to inhibition by the lambda CIII gene product
-
?
phage lambda CII protein + H2O
small peptides of 13-20 amino acid residues
show the reaction diagram
-
recombinant protein substrate with -terminal or C-terminal His-tag, respectively, or no His-tag
product analysis
?
phage shock protein C + H2O
?
show the reaction diagram
PhoA protein + H2O
?
show the reaction diagram
-
-
-
?
Protein + H2O
?
show the reaction diagram
protein + H2O
peptides
show the reaction diagram
protein D1 + H2O
?
show the reaction diagram
protein D2 + H2O
?
show the reaction diagram
protein F0 subunit a + H2O
?
show the reaction diagram
protein F0a + H2O
?
show the reaction diagram
protein FtsZ + H2O
?
show the reaction diagram
protein GgpS + H2O
?
show the reaction diagram
protein GlnK + H2O
?
show the reaction diagram
protein GlpG + H2O
?
show the reaction diagram
helical bundle membrane protein, model membrane substrate
-
-
?
protein KdtA + H2O
?
show the reaction diagram
protein lambdaCII + H2O
?
show the reaction diagram
protein lambdaCIII + H2O
?
show the reaction diagram
protein lambdaXis + H2O
?
show the reaction diagram
protein LpxC + H2O
?
show the reaction diagram
protein MgtC + H2O
?
show the reaction diagram
protein P22 Arc repressor tagged with 108 motif tail + H2O
?
show the reaction diagram
-
tail specific degradation
-
?
protein P22 Arc repressor tagged with SsrA tail + H2O
?
show the reaction diagram
-
tail specific degradation
-
?
protein RpoH + H2O
?
show the reaction diagram
protein SecY + H2O
?
show the reaction diagram
protein sigma 32 + H2O
?
show the reaction diagram
protein sigma32 + H2O
?
show the reaction diagram
protein sigma32 + H2O
peptides
show the reaction diagram
-
regulatory protein
approximately 10 peptides with MW below 3 kDa
?
protein Spo0M + H2O
?
show the reaction diagram
protein translocation subunit SecY + H2O
?
show the reaction diagram
-
-
-
-
?
protein YccA + H2O
?
show the reaction diagram
PspC protein + H2O
?
show the reaction diagram
RpoH protein + H2O
?
show the reaction diagram
-
enzyme recognizes the internal RpoH protein region, N- and C-terminus have no or only marginal effect on substrate binding
-
?
SecY protein + H2O
?
show the reaction diagram
sigma32 + H2O
?
show the reaction diagram
SoxS + H2O
?
show the reaction diagram
-
-
-
-
?
ssrA-tagged Arc + H2O
?
show the reaction diagram
Arc, i.e. a soluble model substrate
-
-
?
ssrA-tagged ProW1-182 + H2O
?
show the reaction diagram
substrate is a truncated variant of multiple-pass inner-membrane protein ProW
-
-
?
subunit a of F0 + H2O
?
show the reaction diagram
-
F0 part of the proton ATPase
-
?
subunit alpha of ATPase F0F1 + H2O
?
show the reaction diagram
-
-
-
-
?
succinate dehydrogenase A + H2O
?
show the reaction diagram
-
-
-
-
?
succinate dehydrogenase B + H2O
?
show the reaction diagram
-
-
-
-
?
succinate dehydrogenase CD + H2O
?
show the reaction diagram
-
-
-
-
?
superoxide response protein + H2O
?
show the reaction diagram
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase + H2O
?
show the reaction diagram
uncomplexed form of the subunit alpha of the proton ATPase F0 + H2O
?
show the reaction diagram
unfolded alpha-casein + H2O
peptides
show the reaction diagram
unfolded pepsin + H2O
peptides
show the reaction diagram
unstable derivatives of the N-terminal domain of the lambdacI repressor + H2O
?
show the reaction diagram
3 derivatives with a nonpolar pentapeptide tail, i.e. cI104, cI105, cI108, and 1 with the SsrAtag, i.e. cI-SsrA
-
?
YccA protein + H2O
?
show the reaction diagram
YccA-(P3)-PhoA + H2O
?
show the reaction diagram
-
recombinant fusion protein
-
?
YfgM protein + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-