3.4.24.B17: FtsH endopeptidase

This is an abbreviated version!
For detailed information about FtsH endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B17

3.4.24.B17

cushing

cortisol-producing

matriptase

ttsps

pro-hgf

prkar1a

ctnnb1

Reaction

proteolytic degradation of proteins =

Synonyms

cell division protein ftsH, FtsH, FtsH protease, FTSH_ECOLI, HflB, HlB, M41.001, MtFtsH, T.ftsH

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.B17 FtsH endopeptidase

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Results	in table
7	Activating Compound
5	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
57	Cofactor
5	Crystallization (Commentary)
2	Expression
18	General Information
18	Inhibitors
6	KM Value [mM]
49	Localization
26	Metals/Ions
3	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
308	Organism
7	pH Optimum
3	Posttranslational Modification
39	Protein Variants
13	Purification (Commentary)
13	Reaction
24	Reaction Type
77	Reference
2	Renatured (Commentary)
12	Specific Activity [micromol/min/mg]
263	Substrates and Products (Substrate)
22	Subunits
100	Synonyms
12	Temperature Optimum [°C]
2	Temperature Range [°C]
8	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.24.B17 - FtsH endopeptidase

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2,4-dinitrophenol

ADP

strong, complete inhibition at equimolar amounts to ATP

651768

ATP

Escherichia coli

inhibitory at high concentration in presence of dimethylsulfoxide

650082

carbonyl cyanide-3-chlorophenylhydrazone

Escherichia coli

antagonist of succinate

653690

Dimethylsulfoxide

Escherichia coli

induces conformational changes, stimulates with SecY as substrate, at concentration up to 20% v/v, slightly inhibitory with casein as a substrate

EDTA

o-phenanthroline

ortho-phenanthroline

phage lambda CIII protein

Escherichia coli

enzyme participates in the phage lambda lysis-lysogeny decision by degrading the CII transcriptional activator and by its response to inhibition by the lambda CIII gene product

651654

protein SecE

Escherichia coli

stabilizes overexpressed SecY against proteolytic degradation by the enzyme, acts a an antagonist

653608

protein SpoVM

2 entries

additional information

3 entries