3.4.24.B17: FtsH endopeptidase
This is an abbreviated version!
For detailed information about FtsH endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.B17
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3.4.24.B17
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cushing
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cortisol-producing
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matriptase
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ttsps
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pro-hgf
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prkar1a
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ctnnb1
- 3.4.24.B17
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cushing
-
cortisol-producing
- matriptase
-
ttsps
-
pro-hgf
-
prkar1a
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ctnnb1
Reaction
proteolytic degradation of proteins =
Synonyms
cell division protein ftsH, FtsH, FtsH protease, FTSH_ECOLI, HflB, HlB, M41.001, MtFtsH, T.ftsH
ECTree
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General Information
General Information on EC 3.4.24.B17 - FtsH endopeptidase
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malfunction
metabolism
physiological function
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expression of doxorubicin resistance protein B alone or doxorubicin resistance protein AB together in FtsH-deficient cells results in growth inhibition
malfunction
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expression of doxorubicin resistance protein B alone or doxorubicin resistance protein AB together in FtsH-deficient cells results in growth inhibition
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the enzyme facilitates refolding of previously misassembled membrane protein doxorubicin resistance protein AB
metabolism
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the enzyme facilitates refolding of previously misassembled membrane protein doxorubicin resistance protein AB
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FtsH controls lipopolysaccharide biosynthesis by proteolysis of LpxC
physiological function
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FtsH is necessary for the processing of colicinsD and E3 during their import into the cytoplasm
physiological function
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FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stres
physiological function
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FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stres
physiological function
FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stres
physiological function
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FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stress
physiological function
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uncomplexed phage shock protein C is deleterious to the bacterial cell and FtsH acts as an important quality control mechanism to remove it
physiological function
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uncomplexed phage shock protein C is deleterious to the bacterial cell and FtsH acts as an important quality control mechanism to remove it
physiological function
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the enzyme is essential for the differentiation of matrix producers and biofilm formation
physiological function
dependence of degradation rates on ATP hydrolysis rates is highly nonlinear. At least, about 20 ATP hydrolysis events need to be accumulated per minute for degradation to occur, but once exceeding the threshold, FtsH tightly couples ATP hydrolysis to degradation in a highly cooperative manner (Hill coefficinet for ATP is 4-5). The degradation rates steeply increase and saturate at the ATP hydrolysis rates far below the maxima. During the steep increase, FtsH efficiently utilizes ATP hydrolysis for degradation, consuming only 40-60% of the total ATP cost measured at the maximal ATP hydrolysis rates
physiological function
Escherichia coli W3110 / ATCC 27325
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FtsH controls lipopolysaccharide biosynthesis by proteolysis of LpxC
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physiological function
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FtsH is necessary for the processing of colicinsD and E3 during their import into the cytoplasm
-
physiological function
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the enzyme is essential for the differentiation of matrix producers and biofilm formation
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physiological function
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uncomplexed phage shock protein C is deleterious to the bacterial cell and FtsH acts as an important quality control mechanism to remove it
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