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3.4.24.B16: protease lasA

This is an abbreviated version!
For detailed information about protease lasA, go to the full flat file.

Word Map on EC 3.4.24.B16

Reaction

proteolytic degradation of proteins =

Synonyms

bacteriolytic enzyme, LasA, LasA endopeptidase, LasA protease, M23.002, Pseudomonas elastase, staphylolysin, staphylolytic enzyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B16 protease lasA

Reference

Reference on EC 3.4.24.B16 - protease lasA

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Carnicero, A.; Mansito, T.B.; Roldan, J.M.; Falcon, M.A.
Staphylolytic enzyme from Pseudomonas aeruginosa: characterization and immunocytochemical localization
Arch. Microbiol.
154
37-41
1990
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Peters, J.E.; Galloway, D.R.
Purification and characterization of an active fragment of the LasA protein from Pseudomonas aeruginosa: enhancement of elastase activity
J. Bacteriol.
172
2236-2240
1990
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Gustin, J.K.; Kessler, E.; Ohman, D.E.
A substitution at His-120 in the LasA protease of Pseudomonas aeruginosa blocks enzymatic activity without affecting propeptide processing or extracellular secretion
J. Bacteriol.
178
6608-6617
1996
Pseudomonas aeruginosa, Pseudomonas aeruginosa FRD1
Manually annotated by BRENDA team
Kessler, E.; Safrin, M.; Abrams, W.R.; Rosenbloom, J.; Ohman, D.E.
Inhibitors and specificity of Pseudomonas aeruginosa LasA
J. Biol. Chem.
272
9884-9889
1997
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Kessler, E.; Safrin, M.; Gustin, J.K.; Ohman, D.E.
Elastase and the LasA protease of Pseudomonas aeruginosa are secreted with their propeptides
J. Biol. Chem.
273
30225-30231
1998
Pseudomonas aeruginosa, Pseudomonas aeruginosa FRD740
Manually annotated by BRENDA team
Peters, J.E.; Park, S.J.; Darzins, A.; Freck, L.C.; Saulnier, J.M.; Wallach, J.M.; Galloway, D.R.
Further studies on Pseudomonas aeruginosa LasA: analysis of specificity
Mol. Microbiol.
6
1155-1162
1992
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Kessler, E.; Safrin, M.; Blumberg, S.; Ohman, D.E.
A continuous spectrophotometric assay for Pseudomonas aeruginosa LasA protease (staphylolysin) using a two-stage enzymatic reaction
Anal. Biochem.
328
225-232
2004
Pseudomonas aeruginosa, Pseudomonas aeruginosa FRD2128(pJKGT107)
Manually annotated by BRENDA team
Barequet, I.S.; Ben Simon, G.J.; Safrin, M.; Ohman, D.E.; Kessler, E.
Pseudomonas aeruginosa LasA protease in treatment of experimental staphylococcal keratitis
Antimicrob. Agents Chemother.
48
1681-1687
2004
Pseudomonas aeruginosa, Pseudomonas aeruginosa FRD2128(pJKGT107)
Manually annotated by BRENDA team
Kessler, E.; Ohman, D.E.
Staphylolysin
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
1001-1003
2004
Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
Elston, C.; Wallach, J.; Saulnier, J.
New continuous and specific fluorometric assays for Pseudomonas aeruginosa elastase and LasA protease
Anal. Biochem.
368
87-94
2007
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Grande, K.K.; Gustin, J.K.; Kessler, E.; Ohman, D.E.
Identification of critical residues in the propeptide of LasA protease of Pseudomonas aeruginosa involved in the formation of a stable mature protease
J. Bacteriol.
189
3960-3968
2007
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Tingpej, P.; Smith, L.; Rose, B.; Zhu, H.; Conibear, T.; Al Nassafi, K.; Manos, J.; Elkins, M.; Bye, P.; Willcox, M.; Bell, S.; Wainwright, C.; Harbour, C.
Phenotypic characterization of clonal and nonclonal Pseudomonas aeruginosa strains isolated from lungs of adults with cystic fibrosis
J. Clin. Microbiol.
45
1697-1704
2007
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Barequet, I.S.; Habot-Wilner, Z.; Mann, O.; Safrin, M.; Ohman, D.E.; Kessler, E.; Rosner, M.
Evaluation of Pseudomonas aeruginosa staphylolysin (LasA protease) in the treatment of methicillin-resistant Staphylococcus aureus endophthalmitis in a rat model
Graefes Arch. Clin. Exp. Ophthalmol.
247
913-917
2009
Pseudomonas aeruginosa (P14789), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Spencer, J.; Murphy, L.M.; Conners, R.; Sessions, R.B.; Gamblin, S.J.
Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases
J. Mol. Biol.
396
908-923
2010
Pseudomonas aeruginosa (P14789)
Manually annotated by BRENDA team
Barequet, I.S.; Bourla, N.; Pessach, Y.N.; Safrin, M.; Yankovich, D.; Ohman, D.E.; Rosner, M.; Kessler, E.
Staphylolysin is an effective therapeutic agent for Staphylococcus aureus experimental keratitis
Graefes Arch. Clin. Exp. Ophthalmol.
250
223-229
2012
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Taganna, J.C.; Quanico, J.P.; Perono, R.M.; Amor, E.C.; Rivera, W.L.
Tannin-rich fraction from Terminalia catappa inhibits quorum sensing (QS) in Chromobacterium violaceum and the QS-controlled biofilm maturation and LasA staphylolytic activity in Pseudomonas aeruginosa
J. Ethnopharmacol.
134
865-871
2011
Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 10145
Manually annotated by BRENDA team
Islamieh, D.I.; Afshar, D.; Esmaeili, D.
Effect of Satureja khuzistanica essential oil (SKEO) extract on expression of lasA and lasB genes in Pseudomonas aeruginosa
Iran. J. Microbiol.
11
55-59
2019
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Radlinski, L.; Rowe, S.E.; Kartchner, L.B.; Maile, R.; Cairns, B.A.; Vitko, N.P.; Gode, C.J.; Lachiewicz, A.M.; Wolfgang, M.C.; Conlon, B.P.
Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus
PLoS Biol.
15
e2003981
2017
Pseudomonas aeruginosa (P14789), Pseudomonas aeruginosa
Manually annotated by BRENDA team