3.4.24.B16: protease lasA
This is an abbreviated version!
For detailed information about protease lasA, go to the full flat file.
Word Map on EC 3.4.24.B16
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3.4.24.B16
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aeruginosa
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elastase
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quorum
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pyocyanin
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lysostaphin
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rhamnolipids
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globisporus
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pyoverdine
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sensing-controlled
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pentaglycine
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lyticus
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qs-controlled
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medicine
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degradation
- 3.4.24.B16
- aeruginosa
- elastase
-
quorum
- pyocyanin
- lysostaphin
- rhamnolipids
- globisporus
-
pyoverdine
-
sensing-controlled
- pentaglycine
- lyticus
-
qs-controlled
- medicine
- degradation
Reaction
proteolytic degradation of proteins =
Synonyms
bacteriolytic enzyme, LasA, LasA endopeptidase, LasA protease, M23.002, Pseudomonas elastase, staphylolysin, staphylolytic enzyme
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Application
Application on EC 3.4.24.B16 - protease lasA
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degradation
medicine
additional information
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cell lysis of Staphylococcus aureus, Micrococcus radiodurans and Gaffkia tetragena
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two-stage enzymatic reaction for the continuous measurement of LasA protease activity using a defined substrate, supplemented with Streptomyces griseus aminopeptidase for further cleavage of the product, rate of release of the chromophore can be measured spectrophotometrically
degradation
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two-stage enzymatic reaction for the continuous measurement of LasA protease activity using a defined substrate, supplemented with Streptomyces griseus aminopeptidase for further cleavage of the product, rate of release of the chromophore can be measured spectrophotometrically
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LasA protease is effective in the treatment of experimental Staphylococcus aureus keratitis in rabbits, in both early- and late-treatment protocols the clinical scores for eyes treated with LasA protease are significantly lower than those for the eyes of corresponding controls
medicine
staphylolysin is effective in the treatment of experimental methicillin-resistant Staphylococcus aureus-induced endophthalmitis in rats, and causes no morphological adverse effects to ocular tissues. Staphylolysin may be beneficial in the treatment of Staphylococcus aureus endophthalmitis in humans
medicine
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LasA protease is an effective therapeutic agent for Staphylococcus aureus experimental keratitis. The enzyme provides long-lasting protection against several strains of Staphylococcus aureus (MSSA, MRSA COL, MRSA 02/48406, and MRSA 02/48103) with IC50 values of 0.0018-0.005 mg/ml
medicine
presence of Pseudomonas aeruginosa alters Staphylococcus aureus susceptibility to bactericidal antibiotics in a variable, strain-dependent manner. LasA endopeptidase potentiates lysis of Staphylococcus aureus by vancomycin. Vancomycin treatment of a Staphylococcus aureus mouse burn infection is potentiated by the presence of a LasA-producing Pseudomonas aeruginosa population
medicine
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the expression of LasA and LasB genes is decreased by Satureja khuzistanica essential oil extract. The MICs of the extract for different multidrug resistant isolates are 8-12 microg/ml
medicine
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LasA protease is effective in the treatment of experimental Staphylococcus aureus keratitis in rabbits, in both early- and late-treatment protocols the clinical scores for eyes treated with LasA protease are significantly lower than those for the eyes of corresponding controls
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