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3.4.24.B15: PHEX peptidase

This is an abbreviated version!
For detailed information about PHEX peptidase, go to the full flat file.

Word Map on EC 3.4.24.B15

Reaction

proteolytic degradation of proteins =

Synonyms

dPHEX, HYP, M13.091, matrix metalloprotease 2 C-terminal hemopexin-like domain, matrix metalloprotease 2 hemopexin domain, metalloendopeptidase homolog PEX, PEX, PHEX, PHEX enzyme, PHEX homologue, phosphate regulating neutral endopeptidase, phosphate-regulating gene with homologies to endiopeptidases on the X chromosome, phosphate-regulating gene with homologies to endo-peptidases on the X chromosome, phosphate-regulating gene with homologies to endopeptidases on the X chromosome, phosphate-regulating gene with homologies to endopeptidases on the X-chromosome, phosphate-regulating neutral endopeptidase, vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B15 PHEX peptidase

Substrates Products

Substrates Products on EC 3.4.24.B15 - PHEX peptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-Gly-Phe-Ser-Asp-Tyr-Lys(Dnp)-OH + H2O
2-aminobenzoyl-Gly-Phe-Ser + Asp-Tyr-Lys(Dnp)-OH
show the reaction diagram
-
-
-
-
?
ASARM peptide + H2O
?
show the reaction diagram
-
-
-
?
aspartate-rich matrix extracellular phosphoglycoprotein-associated motif peptide + H2O
?
show the reaction diagram
-
-
-
-
?
bone sialoprotein + H2O
?
show the reaction diagram
-
-
-
?
DDSHQ(pS)DESHH(pS)DE(pS)DEL + 2 H2O
DDSHQ(pS) + DESHH(pS) + DE(pS)DEL
show the reaction diagram
-
synthetic peptide derived from human osteopontin ASARM motif sequence, cleavage of DDSHQSDESHHSDESDEL and DD(pS)HQ(pS)DE(pS)HH(pS)DE(pS)DEL is also observed
-
-
?
dentin matrix protein 1 + H2O
8 peptides
show the reaction diagram
-
cleavage sites are Phe173-Asp174, Ser180-Asp181, Ser217-Asp218, and Gln221-Asp222
product analysis: four pieces of about 220 amino acid residues and four pieces of about 300 amino acid residues
?
dentin matrix protein-1 + H2O
?
show the reaction diagram
-
-
-
?
dentin sialophosphoprotein + H2O
dentin sialoprotein + dentin phosphoprotein + dentin glycoprotein
show the reaction diagram
-
-
-
?
enamelin + H2O
?
show the reaction diagram
-
-
-
?
matrix extracellular phosphoglycoprotein + H2O
?
show the reaction diagram
-
-
-
?
NH2-RDDSSESSDSGS(PO3H2)SS(PO3H2)ES(PO3H2)DGD-OH + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-A110WLDSGVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-A110WL + DSGVQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on residues 107-139 sequence of the enzyme, cleavage site is the Leu-Asp bond
-
?
o-aminobenzoyl-D124HLSDTSTQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-D124HLS + DTSTQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on residues 107-139 sequence of the enzyme, cleavage site is the Ser-Asp bond
-
?
o-aminobenzoyl-G197QRDSQAQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-G197QR + DSQAQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-G337SNDIMGQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-G337SN + DIMGQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-G386SSDAAEQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-G386SS + DAAEQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-GFSDYK-(2,4-dinitrophenyl)-NH2 + H2O
o-aminobenzoyl-GFS + DYK-(2,4-dinitrophenyl)-NH2
show the reaction diagram
-
cleavage site is the Ser-Asp bond
-
?
o-aminobenzoyl-GFSDYK-(2,4-dinitrophenyl)-OH + H2O
o-aminobenzoyl-GFS + DYK-(2,4-dinitrophenyl)-OH
show the reaction diagram
o-aminobenzoyl-GFSDYQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-GFS + DYQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
cleavage site is the Ser-Asp bond
-
?
o-aminobenzoyl-GFSEY-(2,4-dinitrophenyl)K + H2O
o-aminobenzoyl-GFS + EY-(2,4-dinitrophenyl)K
show the reaction diagram
-
low activity, cleavage site is the Ser-Asp bond
-
?
o-aminobenzoyl-IPSDFEGQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-IPS + DFEGQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-L134ELDSRQ-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-L134EL + DSRQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on residues 107-139 sequence of the enzyme, cleavage site is the Leu-Asp bond
-
?
o-aminobenzoyl-L94MMDFRGQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-L94MM + DFRGQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the FGF-23 protein sequence, cleavage site is the Met-Asp bond
-
?
o-aminobenzoyl-N122GYDVYHQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-N122GY + DVYHQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the FGF-23 protein sequence, cleavage site is the Tyr-Asp bond
-
?
o-aminobenzoyl-N449EMDSFNQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-N449EM + DSFNQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-R175RHTQSAEDDSERQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-R175RHTQSAED + DSERQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the FGF-23 protein sequence, cleavage site is the Asp-Asp bond
-
?
o-aminobenzoyl-R175RHTRSAEDDSERQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-R175RHTRSAED + DSERQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the FGF-23 protein sequence, cleavage site is the Asp-Asp bond
-
?
o-aminobenzoyl-R441GLDNEIQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-R441GL + DNEIQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-R506RDDSSEQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-R506RD + DSSEQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-R76SEDAGFQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-R76SE + DAGFQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the FGF-23 protein sequence, cleavage site is the Glu-Asp bond
-
?
o-aminobenzoyl-S212AEDNSPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-S212AE + DNSPQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the FGF-23 protein sequence, cleavage site is the Glu-Asp bond
-
?
o-aminobenzoyl-S513SDSGSQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-S513S + DSGSQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
o-aminobenzoyl-T294HLDTKKQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
o-aminobenzoyl-T294HL + DTKKQ-N-(2,4-dinitrophenyl)ethylene diamine
show the reaction diagram
-
sequence is based on the MEPE protein sequence
-
?
osteopontin + H2O
?
show the reaction diagram
-
-
-
?
parathyroid-hormone-related peptide 107-139 + H2O
L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-alpha-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-alpha-glutamylglycyl-L-a-aspartyl-L-histidyl-L-leucyl-L-serine + L-alpha-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginine + L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucine + L-alpha-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-alpha-glutamyl-L-leucine + L-alpha-aspartyl-L-seryl-L-arginine
show the reaction diagram
-
-
product determination
?
protein + H2O
peptides
show the reaction diagram
protein FGF-23 + H2O
?
show the reaction diagram
statherin + H2O
?
show the reaction diagram
-
-
-
?
Z-Ala-Ala-Leu-4-nitroanilide + H2O
Z-Ala-Ala-Leu + 4-nitroaniline
show the reaction diagram
-
chromogenic substrate
-
?
ZAAL-4-nitroanilide + H2O
Z-Ala-Ala-Leu + 4-nitroaniline
show the reaction diagram
-
recombinant wild-type enzyme, not the recombinant mutant
-
?
additional information
?
-