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ASARM peptide + H2O
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aspartate-rich matrix extracellular phosphoglycoprotein-associated motif peptide + H2O
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bone sialoprotein + H2O
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dentin matrix protein-1 + H2O
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dentin sialophosphoprotein + H2O
dentin sialoprotein + dentin phosphoprotein + dentin glycoprotein
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matrix extracellular phosphoglycoprotein + H2O
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NH2-RDDSSESSDSGS(PO3H2)SS(PO3H2)ES(PO3H2)DGD-OH + H2O
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osteopontin + H2O
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statherin + H2O
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additional information
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protein + H2O
peptides
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protein + H2O
peptides
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protein + H2O
peptides
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protein + H2O
peptides
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protein + H2O
peptides
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enzyme is involved in pathology of oncogenic osteomalacia, X-linked hypophosphatemia, and autosomal dominant hypophosphatemic rickets
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protein + H2O
peptides
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enzyme mutations are responsible for X-chromosome linked hypophosphataemia
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protein + H2O
peptides
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enzyme mutations are responsible for X-chromosome linked hypophosphataemia by increasing levels of circulating phosphaturic factor
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protein + H2O
peptides
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participates in postsecretory processing, enzyme is involved in regulation of phosphate levels and in bone metabolism
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protein + H2O
peptides
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protein + H2O
peptides
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protein + H2O
peptides
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inactivating mutations cause X-linked hypophosphatemia, i.e. XLH, which results in the local accumulation of an unknown autocrine/paracrine factor in bone that inhibits mineralization of extracellular matrix
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protein + H2O
peptides
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protein FGF-23 + H2O
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i.e. fibroblastic growth factor 23, loss of enzyme activity results in either diminished degradation or increased biosynthesis of FGF-23
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protein FGF-23 + H2O
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additional information
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interacts with integrin alphavbeta3, natural inhibitor of matrix metalloprotease 2, i.e. MMP-2, thereby regulating the invasive behavior of new blood vessels, enzyme domain disrupts angiogenesis and tumor growth
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additional information
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enzyme-deficiency is involved in X-linked hypophosphatemia, XLH, the enzyme inactivates a phosphaturic factor, which may be fibroblast growth factor 23
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additional information
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glycosaminoglycans interact with PHEX, interfering with its enzyme activity, protein stability and cellular trafficking. This interaction may regulate PHEX function influencing the mineralization process
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additional information
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major role of PHEX in X-linked dominant hypophosphatemic rickets
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additional information
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enzyme-deficiency is involved in X-linked hypophosphatemia, Hyp, the enzyme inactivates a phosphaturic factor, which may be fibroblast growth factor 23
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