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3.4.24.B15: PHEX peptidase

This is an abbreviated version!
For detailed information about PHEX peptidase, go to the full flat file.

Word Map on EC 3.4.24.B15

Reaction

proteolytic degradation of proteins =

Synonyms

dPHEX, HYP, M13.091, matrix metalloprotease 2 C-terminal hemopexin-like domain, matrix metalloprotease 2 hemopexin domain, metalloendopeptidase homolog PEX, PEX, PHEX, PHEX enzyme, PHEX homologue, phosphate regulating neutral endopeptidase, phosphate-regulating gene with homologies to endiopeptidases on the X chromosome, phosphate-regulating gene with homologies to endo-peptidases on the X chromosome, phosphate-regulating gene with homologies to endopeptidases on the X chromosome, phosphate-regulating gene with homologies to endopeptidases on the X-chromosome, phosphate-regulating neutral endopeptidase, vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B15 PHEX peptidase

General Information

General Information on EC 3.4.24.B15 - PHEX peptidase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
in squamous cell carcinoma cells, PHEX is degraded by endogenous cysteine proteases. Inhibition of cysteine proteases rescues membrane PHEX and osteopontin processing
physiological function