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3.4.24.B15: PHEX peptidase

This is an abbreviated version!
For detailed information about PHEX peptidase, go to the full flat file.

Word Map on EC 3.4.24.B15

Reaction

proteolytic degradation of proteins =

Synonyms

dPHEX, HYP, M13.091, matrix metalloprotease 2 C-terminal hemopexin-like domain, matrix metalloprotease 2 hemopexin domain, metalloendopeptidase homolog PEX, PEX, PHEX, PHEX enzyme, PHEX homologue, phosphate regulating neutral endopeptidase, phosphate-regulating gene with homologies to endiopeptidases on the X chromosome, phosphate-regulating gene with homologies to endo-peptidases on the X chromosome, phosphate-regulating gene with homologies to endopeptidases on the X chromosome, phosphate-regulating gene with homologies to endopeptidases on the X-chromosome, phosphate-regulating neutral endopeptidase, vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B15 PHEX peptidase

Cloned

Cloned on EC 3.4.24.B15 - PHEX peptidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA determination and analysis, expression of wild-type and C-terminally truncated mutant as His-tagged protein in Spodoptera frugiperda Sf9 cells via baculovirus infection
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dPHEX1-3, localization on the X-chromosome, genomic organization, DNA and amino acid sequence determination and analysis, expression profiles of the isozymes in embryonic developmental stages, expression of FLAG-tagged isozymes in S2 cells
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expression as V5-epitope tagged enzyme in an in vitro rabbit reticulocyte lysate system
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expression in CHO cells
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expression in HEK.293 cell
expression of wild-type and mutant enzyme in Spodoptera frugiperda Sf9 cells via baculovirus infection, recombinant enzyme is located in the membranes of the Sf9 cells
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functional in vitro expression by a reticulocyte lysate expression system, protein expressed in COS-7 cells is not functional
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gene PEX mapps to chromosome region Xp22.1
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gene PHEX, localization on the X chromosome, overexpression under control of the human beta-actin promoter in transgenic mice in all tissue except for pancreas, ovary and brain
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PHEX gene, expression of wild-type and mutants in LLC-PK1 porcine kidney cells
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PHEX gene, i.e. phosphate-regulating gene with homologies to endopeptidase on the X-chromosome, expression as soluble secreted mutant form secPHEX, lacking residues 1-45, in LLC-PK1 porcine kidney cells, deletion mutant enzyme shows catalytic properties similar to the wild-type enzyme
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the gene is localized on the X chromosome
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