Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.24.B14: neprilysin-2

This is an abbreviated version!
For detailed information about neprilysin-2, go to the full flat file.

Word Map on EC 3.4.24.B14

Reaction

proteolytic degradation of proteins =

Synonyms

M13.008, membrane metallo-endopeptidase-like protein, membrane-bound metalloendopeptidase-like enzyme 1, membrane-bound metalloendopeptidase-like enzyme 2, MMEL, MMEL1, MMEL2, More, NEP-like endopeptidase, NEP2, NEP2(s), NEPII, NEPLP, neprilysin 2, neprilysin-2, neprilysin-like protein, NL-1, Nl1, NL1 protein, SEP, soluble-secreted endopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B14 neprilysin-2

Reference

topprint

Reference on EC 3.4.24.B14 - neprilysin-2

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (Q9JLI3)
Manually annotated by BRENDA team
Ikeda, K.; Emoto, N.; Raharjo, S.B.; Nurhantari, Y.; Saiki, K.; Yokoyama, M.; Matsuo, M.
Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
J. Biol. Chem.
274
32469-32477
1999
Mus musculus (Q9JLI3)
Manually annotated by BRENDA team
Voisin, S.; Ouimet, T.
The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity
Biochem. Biophys. Res. Commun.
335
356-360
2005
Rattus norvegicus
Manually annotated by BRENDA team
Thomas, J.E.; Rylett, C.M.; Carhan, A.; Bland, N.D.; Bingham, R.J.; Shirras, A.D.; Turner, A.J.; Isaac, R.E.
Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function
Biochem. J.
386
357-366
2005
Drosophila melanogaster
Manually annotated by BRENDA team
Voisin, S.; Rognan, D.; Gros, C.; Ouimet, T.
A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2
J. Biol. Chem.
279
46172-46181
2004
Rattus norvegicus
Manually annotated by BRENDA team
Carpentier, M.; Guillemette, C.; Bailey, J.L.; Boileau, G.; Jeannotte, L.; DesGroseillers, L.; Charron, J.
Reduced fertility in male mice deficient in the zinc metallopeptidase NL1
Mol. Cell. Biol.
24
4428-4437
2004
Mus musculus
Manually annotated by BRENDA team
Oh-Hashi, K.; Ohkubo, K.; Shizu, K.; Fukuda, H.; Hirata, Y.; Kiuchi, K.
Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2
Mol. Cell. Biochem.
313
103-111
2008
Mus musculus
Manually annotated by BRENDA team
Bland, N.D.; Thomas, J.E.; Audsley, N.; Shirras, A.D.; Turner, A.J.; Isaac, R.E.
Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster
Peptides
28
127-135
2007
Drosophila melanogaster, Drosophila melanogaster OregonR
Manually annotated by BRENDA team
Ouimet, T.; Facchinetti, P.; Rose, C.; Bonhomme, M.C.; Gros, C.; Schwartz, J.C.
Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis
Biochem. Biophys. Res. Commun.
271
565-570
2000
Rattus norvegicus (P0C1T0)
Manually annotated by BRENDA team
Rose, C.; Voisin, S.; Gros, C.; Schwartz, J.C.; Ouimet, T.
Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin
Biochem. J.
363
697-705
2002
Rattus norvegicus (P0C1T0)
Manually annotated by BRENDA team
Whyteside, A.R.; Turner, A.J.
Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences
FEBS Lett.
582
2382-2386
2008
Homo sapiens (Q495T6), Homo sapiens
Manually annotated by BRENDA team
Bland, N.D.; Robinson, P.; Thomas, J.E.; Shirras, A.D.; Turner, A.J.; Isaac, R.E.
Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2
Peptides
30
571-574
2009
Drosophila melanogaster (Q9XZ01), Drosophila melanogaster
Manually annotated by BRENDA team
Hafez, D.; Huang, J.Y.; Huynh, A.M.; Valtierra, S.; Rockenstein, E.; Bruno, A.M.; Lu, B.; DesGroseillers, L.; Masliah, E.; Marr, R.A.
Neprilysin-2 is an important beta-amyloid degrading enzyme
Am. J. Pathol.
178
306-312
2011
Mus musculus
Manually annotated by BRENDA team
Huang, J.Y.; Hafez, D.M.; James, B.D.; Bennett, D.A.; Marr, R.A.
Altered NEP2 Expression and Activity in Mild Cognitive Impairment and Alzheimers Disease
J. Alzheimers Dis.
28
433-441
2012
Homo sapiens
Manually annotated by BRENDA team
Marr, R.A.; Hafez, D.M.
Amyloid-beta and Alzheimers disease: the role of neprilysin-2 in amyloid-beta clearance
Front. Aging Neurosci.
6
187
2014
Homo sapiens (Q495T6), Mus musculus (Q9JLI3)
Manually annotated by BRENDA team
Takamatsu, K.; Ikeda, T.; Haruta, M.; Matsumura, K.; Ogi, Y.; Nakagata, N.; Uchino, M.; Ando, Y.; Nishimura, Y.; Senju, S.
Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing neprilysin-2
Stem Cell Res.
13
442-453
2014
Homo sapiens (Q495T6), Homo sapiens
Manually annotated by BRENDA team
Ul-Haq, Z.; Usmani, S.; Iqbal, S.; Zia, S.R.
In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity
Mol. Biosyst.
12
1024-1036
2016
Homo sapiens (Q495T6), Homo sapiens
Manually annotated by BRENDA team