3.4.24.B14: neprilysin-2
This is an abbreviated version!
For detailed information about neprilysin-2, go to the full flat file.
![](word_maps/png/3_4_24_B14.png)
Word Map on EC 3.4.24.B14
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3.4.24.B14
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neprilysins
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alzheimer
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endopeptidases
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amyloid
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thiorphan
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phosphoramidon
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metalloproteases
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neuropeptides
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3.4.24.11
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zinc-dependent
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medicine
- 3.4.24.B14
- neprilysins
- alzheimer
- endopeptidases
-
amyloid
- thiorphan
- phosphoramidon
- metalloproteases
- neuropeptides
-
3.4.24.11
-
zinc-dependent
- medicine
Reaction
proteolytic degradation of proteins =
Synonyms
M13.008, membrane metallo-endopeptidase-like protein, membrane-bound metalloendopeptidase-like enzyme 1, membrane-bound metalloendopeptidase-like enzyme 2, MMEL, MMEL1, MMEL2, More, NEP-like endopeptidase, NEP2, NEP2(s), NEPII, NEPLP, neprilysin 2, neprilysin-2, neprilysin-like protein, NL-1, Nl1, NL1 protein, SEP, soluble-secreted endopeptidase
ECTree
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Localization
Localization on EC 3.4.24.B14 - neprilysin-2
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human neprilysin-2-beta is either localized to the extracellular surface or secreted
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
additional information
human neprilysin-2-beta is either localized to the extracellular surface or secreted
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![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
due to alternative splicing, murine NEP2 can exist in a membrane-bound form (mNEP2-alpha) or a secreted form (mNEP2-beta)
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![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
NEP2 exists as a membrane-bound and soluble enzyme, isoform NEP2DELTA exists as two membrane-bound glycoforms glycoforms, localised to the ER and plasma membrane
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
due to alternative splicing, murine NEP2 can exist in a membrane-bound form (mNEP2-alpha) or a secreted form (mNEP2-beta)
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
alternative splicing acts on the human form of neprilysin-2 creating several isoforms. Isoform hNEP2-gamma does not show secreted amyloid beta peptide-degrading activity or activity at the cell surface
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![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
additional information
neprilysin-2 has two alternatively spliced forms, a membrane-bound and soluble-secreted variant
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![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
additional information
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neprilysin-2 has two alternatively spliced forms, a membrane-bound and soluble-secreted variant
-
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)