3.4.24.B14: neprilysin-2
This is an abbreviated version!
For detailed information about neprilysin-2, go to the full flat file.
Word Map on EC 3.4.24.B14
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3.4.24.B14
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neprilysins
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alzheimer
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endopeptidases
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amyloid
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thiorphan
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phosphoramidon
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metalloproteases
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neuropeptides
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3.4.24.11
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zinc-dependent
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medicine
- 3.4.24.B14
- neprilysins
- alzheimer
- endopeptidases
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amyloid
- thiorphan
- phosphoramidon
- metalloproteases
- neuropeptides
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3.4.24.11
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zinc-dependent
- medicine
Reaction
proteolytic degradation of proteins =
Synonyms
M13.008, membrane metallo-endopeptidase-like protein, membrane-bound metalloendopeptidase-like enzyme 1, membrane-bound metalloendopeptidase-like enzyme 2, MMEL, MMEL1, MMEL2, More, NEP-like endopeptidase, NEP2, NEP2(s), NEPII, NEPLP, neprilysin 2, neprilysin-2, neprilysin-like protein, NL-1, Nl1, NL1 protein, SEP, soluble-secreted endopeptidase
ECTree
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General Information
General Information on EC 3.4.24.B14 - neprilysin-2
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evolution
malfunction
metabolism
physiological function
additional information
neprilysin-2 is also a zinc metalloendopeptidase belonging to the same M13 family as neprilysin
evolution
neprilysin-2 is also a zinc metalloendopeptidase belonging to the same M13 family as neprilysin
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mice deficient for the NEP2 gene show significant elevations in total amyloid-beta peptide species in the hippocampus and brainstem/diencephalon (1.5fold). Increases in amyloid-beta peptide accumulation are more dramatic in NEP2 knockout mice crossbred with APP transgenic mice. In NEP/NEP2 double-knockout mice, amyloid-beta peptide levels are marginally increased (1.5 to 2fold), compared with NEP-/-/NEP2+/+ controls. Treatment of these double-knockout mice with phosphoramidon results in elevations of amyloid-beta peptide, suggesting that yet other NEP-like amyloid-beta peptide -degrading endopeptidases are contributing to amyloid-beta peptide catabolism
malfunction
reduced enzyme activity in association with mild-cognitive impaired subjects and Alzheimer's disease subjects regardless of sex
neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP, EC 3.4.24.11) to control amyloid-beta peptide levels in the brain
metabolism
neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP, EC 3.4.24.11) to control amyloid-beta peptide levels in the brain
metabolism
neprilysin-2 (NEP2) in the central nervous system controls Alzheimer's protein (amyloid-beta) deposition, and prevents its occurrence, while in the peripheral system, its closest homologue, neutral endopeptidase neprilysin (NEP, EC 3.4.24.11), regulates hypertension and heart related diseases
NEP-like proteases, e.g. neprilysin-2, are important because of their potential involvement in the spike in amyloid beta peptide levels posttreatment with NEP inhibitors. Neprilysin-2 has importance in amyloid peptide regulation
physiological function
NEP-like proteases, e.g. neprilysin-2, are important because of their potential involvement in the spike in amyloid beta peptide levels posttreatment with NEP inhibitors. The enzyme might play a role in the metabolism of neuropeptides of the hypothalamo-pituitary axis
physiological function
neprilysin-2 (NEP2) in the central nervous system controls Alzheimer's protein (amyloid-beta) deposition, and prevents its occurrence
enzyme splice variants and their involvement in amloid beta peptide cleavage, overview
additional information
enzyme splice variants and their involvement in amyloid beta peptide cleavage, overview
additional information
molecular dynamics (MD) simulations of NEP-2 and modelling, overview. For substrate and inhibitor binding, Arg661 and Zn694 are identified as the most conserved residues
additional information
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molecular dynamics (MD) simulations of NEP-2 and modelling, overview. For substrate and inhibitor binding, Arg661 and Zn694 are identified as the most conserved residues