3.4.24.B14: neprilysin-2

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For detailed information about neprilysin-2, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M13.008, membrane metallo-endopeptidase-like protein, membrane-bound metalloendopeptidase-like enzyme 1, membrane-bound metalloendopeptidase-like enzyme 2, MMEL, MMEL1, MMEL2, More, NEP-like endopeptidase, NEP2, NEP2(s), NEPII, NEPLP, neprilysin 2, neprilysin-2, neprilysin-like protein, NL-1, Nl1, NL1 protein, SEP, soluble-secreted endopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B14 neprilysin-2

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Results	in table
3	AA Sequence
1	Application
2	CAS Registry Number
9	Cloned(Commentary)
18	Disease/ Diagnostics
2	Expression
15	General Information
6	IC50 Value
57	Inhibitors
35	Ki Value [mM]
12	KM Value [mM]
20	Localization
3	Metals/Ions
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
19	Organism
2	pH Optimum
1	pH Stability
7	Posttranslational Modification
4	Protein Variants
2	Purification (Commentary)
1	Reaction
2	Reaction Type
19	Reference
33	Source Tissue
65	Substrates and Products (Substrate)
1	Subunits
44	Synonyms
1	Temperature Optimum [°C]
30	Turnover Number [1/s]

Expression

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Expression on EC 3.4.24.B14 - neprilysin-2

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

NEP2 expression is measured in non-impaired, mild cognitive impaired, and clinical Alzheimer's disease human brain tissue from two Alzheimer's disease -susceptible and two resistant regions. NEP2 and NEP mRNA expression is altered in mild cognitive impaired subjects relative to non-impaired subjects in Alzheimer's disease -susceptible regions. NEP2 enzymatic activity is lowered in association with mild cognitive impaired and Alzheimer's disease and is positively associated with cognitive function, independent of diagnostic category

Homo sapiens

-

717700

the altered enzyme expression has a sexually dimorphic change, with mild-cognitive impaired males having significantly elevated NEP2 mRNA levels compared to non-impaired males in the mid-temporal and mid-frontal gyri

Homo sapiens

Q495T6

733906