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3.4.24.B14: neprilysin-2

This is an abbreviated version!
For detailed information about neprilysin-2, go to the full flat file.

Word Map on EC 3.4.24.B14

Reaction

proteolytic degradation of proteins =

Synonyms

M13.008, membrane metallo-endopeptidase-like protein, membrane-bound metalloendopeptidase-like enzyme 1, membrane-bound metalloendopeptidase-like enzyme 2, MMEL, MMEL1, MMEL2, More, NEP-like endopeptidase, NEP2, NEP2(s), NEPII, NEPLP, neprilysin 2, neprilysin-2, neprilysin-like protein, NL-1, Nl1, NL1 protein, SEP, soluble-secreted endopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B14 neprilysin-2

Disease

Disease on EC 3.4.24.B14 - neprilysin-2

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance.
Arthritis, Rheumatoid
Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population.
Celiac Disease
Replication of GWAS Coding SNPs Implicates MMEL1 as a Potential Susceptibility Locus among Saudi Arabian Celiac Disease Patients.
Liver Cirrhosis
Genetic Risk Factors for Autoimmune Thyroid Disease might Affect the Susceptibility to and Modulate the Progression of Primary Biliary Cholangitis.
Liver Cirrhosis, Biliary
Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
Multiple Sclerosis
Investigating the association of polymorphisms of ANKRD55 and MMEL1 with susceptibility to multiple sclerosis in Iranian population.
Neuroblastoma
Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family.
Osteochondrodysplasias
Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family.