3.4.24.B14: neprilysin-2

This is an abbreviated version!
For detailed information about neprilysin-2, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M13.008, membrane metallo-endopeptidase-like protein, membrane-bound metalloendopeptidase-like enzyme 1, membrane-bound metalloendopeptidase-like enzyme 2, MMEL, MMEL1, MMEL2, More, NEP-like endopeptidase, NEP2, NEP2(s), NEPII, NEPLP, neprilysin 2, neprilysin-2, neprilysin-like protein, NL-1, Nl1, NL1 protein, SEP, soluble-secreted endopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B14 neprilysin-2

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Results	in table
3	AA Sequence
1	Application
2	CAS Registry Number
9	Cloned(Commentary)
18	Disease/ Diagnostics
2	Expression
15	General Information
6	IC50 Value
57	Inhibitors
35	Ki Value [mM]
12	KM Value [mM]
20	Localization
3	Metals/Ions
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
19	Organism
2	pH Optimum
1	pH Stability
7	Posttranslational Modification
4	Protein Variants
2	Purification (Commentary)
1	Reaction
2	Reaction Type
19	Reference
33	Source Tissue
65	Substrates and Products (Substrate)
1	Subunits
44	Synonyms
1	Temperature Optimum [°C]
30	Turnover Number [1/s]

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Cloned on EC 3.4.24.B14 - neprilysin-2

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Rattus norvegicus

P0C1T0

690691

expressed in HEK293 cells

Mus musculus

-

681904

expressed in S2 cells

Drosophila melanogaster

-

682251

expression in Drosophila melanogaster S2 cells

Drosophila melanogaster

-

667494

expression of both isoforms, NEP2 and NEP2DELTA

Homo sapiens

Q495T6

692350

expression of two alternatively spliced isoforms of NEP2 in Chinese hamster ovary and AtT20 cells

Rattus norvegicus

P0C1T0

690798

expression of wild-type and mutated forms of rNEP2 in AtT20 cells

Rattus norvegicus

-

667419

isozymes SEP and SEPDELTA, DNA determination and analysis, transient expression of both isoforms in CHO cells

Mus musculus

Q9JLI3

651958

neprilysin-2 expression in human induced pluripotent stem (iPS) cell-derived macrophage-like cells which leads to secretion of the enzyme, to reduced level of soluble amyloid beta oligomer in the culture medium, and to alleviated neurotoxicity of amyloid beta. Intracerebrally administration of the iPS-ML/NEP2 cells to 5XFAD mice leading to significant reduction in the level of amyloid beta in the brain interstitial fluid. 5XFAD mice harbor three mutations in the amyloid precursor protein (APP) gene and two in the presenilin-1 (PS1) gene and are a mouse model of Alzheimer's disease

Homo sapiens

Q495T6

735280