3.4.24.B12: ADAMTS5 endopeptidase

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For detailed information about ADAMTS5 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B12

3.4.24.B12

cartilage

osteoarthritis

chondrocytes

articular

metalloproteinase

collagen

joint

disintegrin

degeneration

adamts-4

tnf

proteoglycans

knee

intervertebral

degener

synovial

cox-2

mmp-1

col2a1

pulposus

meniscus

interleukin-1

intra-articular

versican

disintegrin-like

timp-3

temporomandibular

subchondral

safranin

cruciate

matrix-degrading

neoepitope

chondroprotective

chondrogenic

brevican

medicine

mankin

surgically-induced

oa-like

collagen-ii

meniscectomy

anti-catabolic

cartilage-degrading

interglobular

dmm-induced

condylar

oa-related

oa-associated

osteophyte

motifs-4

osteoarthritis-like

Reaction

proteolytic degradation of proteins =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs-5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5, a disintegrin and metalloproteinase with thrombospondin-1 motifs 5, a disintegrin-like and metalloproteinase with thrombospondin-1 motifs 5, ADAM-TS 5, ADAM-TS11, ADAM-TS5, adamalysin with thrombospondin type 1 motifs-5, ADAMTS-11, ADAMTS-5, ADAMTS-5(p45), ADAMTS-5(p60), ADAMTS-5(p85), ADAMTS-5-2, ADAMTS11, ADAMTS5, ADMP-2, Agg-2, aggrecanase 2, aggrecanase-, aggrecanase-2, implantin, M12.225

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.B12 ADAMTS5 endopeptidase

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Results	in table
17	Activating Compound
7	AA Sequence
12	Application
1	CAS Registry Number
20	Cloned(Commentary)
5	Crystallization (Commentary)
752	Disease/ Diagnostics
7	Expression
20	General Information
178	IC50 Value
230	Inhibitors
19	Ki Value [mM]
8	Localization
4	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
79	Organism
9	pH Optimum
6	Posttranslational Modification
3	Protein Variants
14	Purification (Commentary)
2	Reaction
9	Reaction Type
77	Reference
2	Renatured (Commentary)
70	Source Tissue
1	Specific Activity [micromol/min/mg]
89	Substrates and Products (Substrate)
6	Subunits
148	Synonyms
11	Temperature Optimum [°C]

Purification

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Purification on EC 3.4.24.B12 - ADAMTS5 endopeptidase

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3 entries

anti-FLAG M2-agarose column chromatography, Macro-Prep 25 S resin chromatography, and

Homo sapiens

680923

cation exchange chromatography and anion exchange chromatography

gel filtration

immunoprecipitation

M2-agarose column chromatography, Macro-Prep S resin column chromatography, and Sephacryl S-200 gel filtration

Homo sapiens

680781

Ni-NTA affinity chromatography

Homo sapiens

677997

partially, recombinant His-tagged enzyme from insect cells, 185fold

Homo sapiens

Q9UNA0

651153

recombinant FLAG-tagged from insect Sf9 cells

Homo sapiens

651091

Sephacryl S-200 HR gel filtration

Homo sapiens

680903

Strep-Tactin affinity chromatography and Superdex-200 gel filtration

Homo sapiens

682743