3.4.24.B12: ADAMTS5 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS5 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B12

3.4.24.B12

cartilage

osteoarthritis

chondrocytes

articular

metalloproteinase

collagen

joint

disintegrin

degeneration

adamts-4

tnf

proteoglycans

knee

intervertebral

degener

synovial

cox-2

mmp-1

col2a1

pulposus

meniscus

interleukin-1

intra-articular

versican

disintegrin-like

timp-3

temporomandibular

subchondral

safranin

cruciate

matrix-degrading

neoepitope

chondroprotective

chondrogenic

brevican

medicine

mankin

surgically-induced

oa-like

collagen-ii

meniscectomy

anti-catabolic

cartilage-degrading

interglobular

dmm-induced

condylar

oa-related

oa-associated

osteophyte

motifs-4

osteoarthritis-like

Reaction

proteolytic degradation of proteins =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs-5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5, a disintegrin and metalloproteinase with thrombospondin-1 motifs 5, a disintegrin-like and metalloproteinase with thrombospondin-1 motifs 5, ADAM-TS 5, ADAM-TS11, ADAM-TS5, adamalysin with thrombospondin type 1 motifs-5, ADAMTS-11, ADAMTS-5, ADAMTS-5(p45), ADAMTS-5(p60), ADAMTS-5(p85), ADAMTS-5-2, ADAMTS11, ADAMTS5, ADMP-2, Agg-2, aggrecanase 2, aggrecanase-, aggrecanase-2, implantin, M12.225

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.B12 ADAMTS5 endopeptidase

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Results	in table
17	Activating Compound
7	AA Sequence
12	Application
1	CAS Registry Number
20	Cloned(Commentary)
5	Crystallization (Commentary)
752	Disease/ Diagnostics
7	Expression
20	General Information
178	IC50 Value
230	Inhibitors
19	Ki Value [mM]
8	Localization
4	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
79	Organism
9	pH Optimum
6	Posttranslational Modification
3	Protein Variants
14	Purification (Commentary)
2	Reaction
9	Reaction Type
77	Reference
2	Renatured (Commentary)
70	Source Tissue
1	Specific Activity [micromol/min/mg]
89	Substrates and Products (Substrate)
6	Subunits
148	Synonyms
11	Temperature Optimum [°C]

Molecular Weight

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Molecular Weight on EC 3.4.24.B12 - ADAMTS5 endopeptidase

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105000

Homo sapiens

SDS-PAGE, pro-form of ADAMTS-5

668982

45000

Homo sapiens

Q9UNA0

SDS-PAGE, C-terminally truncated isoform of ADAMTS-5

60000

64000

x * 64000, C-terminally processed recombinant mature enzyme, SDS-PAGE

70000

x * 70000, SDS-PAGE

73000

SDS-PAGE, deglycosylated full length recombinant human ADAMTS-5

667827

74000

2 entries

75000

Homo sapiens

SDS-PAGE, glycosylated active form of ADAMTS-5

668982

81000

Homo sapiens

recombinant enzyme, SDS-PAGE

680923

85000

Homo sapiens

Q9UNA0

SDS-PAGE, full length recombinant human ADAMTS-5

667827