3.4.24.B12: ADAMTS5 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS5 endopeptidase, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs-5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5, a disintegrin and metalloproteinase with thrombospondin-1 motifs 5, a disintegrin-like and metalloproteinase with thrombospondin-1 motifs 5, ADAM-TS 5, ADAM-TS11, ADAM-TS5, adamalysin with thrombospondin type 1 motifs-5, ADAMTS-11, ADAMTS-5, ADAMTS-5(p45), ADAMTS-5(p60), ADAMTS-5(p85), ADAMTS-5-2, ADAMTS11, ADAMTS5, ADMP-2, Agg-2, aggrecanase 2, aggrecanase-, aggrecanase-2, implantin, M12.225

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B12 ADAMTS5 endopeptidase

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Results	in table
17	Activating Compound
7	AA Sequence
12	Application
1	CAS Registry Number
20	Cloned(Commentary)
5	Crystallization (Commentary)
752	Disease/ Diagnostics
7	Expression
20	General Information
178	IC50 Value
230	Inhibitors
19	Ki Value [mM]
8	Localization
4	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
79	Organism
9	pH Optimum
6	Posttranslational Modification
3	Protein Variants
14	Purification (Commentary)
2	Reaction
9	Reaction Type
77	Reference
2	Renatured (Commentary)
70	Source Tissue
1	Specific Activity [micromol/min/mg]
89	Substrates and Products (Substrate)
6	Subunits
148	Synonyms
11	Temperature Optimum [°C]

KI Value

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KI Value on EC 3.4.24.B12 - ADAMTS5 endopeptidase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000093

(2R)-N4-hydroxy-2-(3-hydroxybenzyl)-N1-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide

Homo sapiens

Q9UNA0

or above, pH not specified in the publication, temperature not specified in the publication

734700

0.000017

(2S,3R)-2-[(cyclopropylmethyl)amino]-N1-hydroxy-N4-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-methylbutanediamide

Homo sapiens

Q9UNA0

or above, pH not specified in the publication, temperature not specified in the publication

734700

0.0012 - 0.0111

(E)-4-[2-(3,5-dihydroxyphenyl)ethenyl]1,2-benzenediol

2 entries

0.000106

marimastat

Homo sapiens

Q9UNA0

pH not specified in the publication, temperature not specified in the publication

734700

0.00013 - 0.00101

N-terminal domain of tissue inhibitor of metalloproteinases-3

5 entries

-

0.00363 - 0.037

pyrogallol

2 entries

0.00000066

TIMP-3

Homo sapiens

-

pH 7.5, 37°C

652102

-

0.00063 - 0.00117

tissue inhibitor of metalloproteinases-3

5 entries

-

additional information

additional information

2 entries

-

0.0012

(E)-4-[2-(3,5-dihydroxyphenyl)ethenyl]1,2-benzenediol

Sus scrofa

-

pH 7.5, 37°C, substrate: C6-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-Gly-Thr-Lys(7-methoxycoumarin-4-yl)-Gly-Glu–Leu–Glu–Gly-Arg–Gly-Thr-Lys(Dnp)-Gly-Ile-Ser-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-NH2

708082

0.0111

(E)-4-[2-(3,5-dihydroxyphenyl)ethenyl]1,2-benzenediol

Sus scrofa

-

pH 7.5, 37°C, substrate: pH 7.5, 37°C, substrate: Lys(7-methoxycoumarin-4-yl)-Lys-Gln-Glu-Phe-Arg-Gly-Gln-Thr-Lys(Dnp)-NH2

708082

0.00013

N-terminal domain of tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-1

709790

-

0.00029

N-terminal domain of tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-3

709790

-

0.00035

N-terminal domain of tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-2

709790

-

0.0004

N-terminal domain of tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-4

709790

-

0.00101

N-terminal domain of tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-5

709790

-

0.00363

pyrogallol

Sus scrofa

-

pH 7.5, 37°C, substrate: C6-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-Gly-Thr-Lys(7-methoxycoumarin-4-yl)-Gly-Glu–Leu–Glu–Gly-Arg–Gly-Thr-Lys(Dnp)-Gly-Ile-Ser-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-NH2

708082

0.037

pyrogallol

Sus scrofa

-

pH 7.5, 37°C, substrate: Lys(7-methoxycoumarin-4-yl)-Lys-Gln-Glu-Phe-Arg-Gly-Gln-Thr-Lys(Dnp)-NH2

708082

0.00063

tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-1

709790

-

0.00072

tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-2

709790

-

0.001

tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-3

709790

-

0.00113

tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-4

709790

-

0.00117

tissue inhibitor of metalloproteinases-3

Homo sapiens

-

pH 7.5, 37°C, isoenzyme ADAMTS5-5

709790

-

additional information

additional information

Homo sapiens

Q9UNA0

Ki(app) of N-terminal alanine-extension mutants and of position [-1] mutants of N-terminal inhibitory domain of tissue inhibitor of metalloproteinases 3

707445

-

additional information

additional information

Homo sapiens

-

Ki(app) of N-terminal alanine-extension mutants and of position [-1] mutants of N-terminal inhibitory domain of tissue inhibitor of metalloproteinases 3

707445

-