3.4.24.B12: ADAMTS5 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS5 endopeptidase, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs-5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5, a disintegrin and metalloproteinase with thrombospondin-1 motifs 5, a disintegrin-like and metalloproteinase with thrombospondin-1 motifs 5, ADAM-TS 5, ADAM-TS11, ADAM-TS5, adamalysin with thrombospondin type 1 motifs-5, ADAMTS-11, ADAMTS-5, ADAMTS-5(p45), ADAMTS-5(p60), ADAMTS-5(p85), ADAMTS-5-2, ADAMTS11, ADAMTS5, ADMP-2, Agg-2, aggrecanase 2, aggrecanase-, aggrecanase-2, implantin, M12.225

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B12 ADAMTS5 endopeptidase

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Results	in table
17	Activating Compound
7	AA Sequence
12	Application
1	CAS Registry Number
20	Cloned(Commentary)
5	Crystallization (Commentary)
752	Disease/ Diagnostics
7	Expression
20	General Information
178	IC50 Value
230	Inhibitors
19	Ki Value [mM]
8	Localization
4	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
79	Organism
9	pH Optimum
6	Posttranslational Modification
3	Protein Variants
14	Purification (Commentary)
2	Reaction
9	Reaction Type
77	Reference
2	Renatured (Commentary)
70	Source Tissue
1	Specific Activity [micromol/min/mg]
89	Substrates and Products (Substrate)
6	Subunits
148	Synonyms
11	Temperature Optimum [°C]

Expression

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Expression on EC 3.4.24.B12 - ADAMTS5 endopeptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

ADAMTS-5 expression is not regulated by interleukin-1 and tumor necrosis factor-alpha

Homo sapiens

-

720093

Adamts5 mRNA is superinduced in Fgf2–/– mice compared with Fgf2+/+ (fibroblast growth factor 2) mice 2 weeks following surgical destabilization of the medial meniscus

Mus musculus

-

707317

ADAMTS5 protein within cartilage increases following injury and with coculture

Bos taurus

-

707277

disruption of chondrocyte hyaluran receptor CD44-hyaluran interactions with hyaluran oligosaccharides induces the transcription of endopeptidases ADAMTS-4 and ADAMTS-5 in a time- and dose-dependent manner

Bos taurus

-

733229

fibroblast growth factor 2 inhibits ADAMTS-5 expression in isolated aortic smooth muscle cells and blocks the spontaneous release of ADAMTS-generated versican and aggrecan fragments from aortic explants

Mus musculus

-

734180

interleukin-1beta+OSM and tumor necrosis factor alpha+ OSM treatments induces a 17fold and 13fold increase in ADAMTS5 gene expression. Relatively little modulation in ADAMTS5 expression is observed in the presence of interleukin-1beta, tumor necrosis factor alpha or OSM alone

Homo sapiens

-

719385

the enzyme is expressed 2.1fold less in Sertoli cells of individuals with nonobstructive azoospermia than those of control individuals with obstructive azoospermia

Homo sapiens

Q8TE58

755570