3.4.24.B12: ADAMTS5 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS5 endopeptidase, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs-5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 5, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5, a disintegrin and metalloproteinase with thrombospondin-1 motifs 5, a disintegrin-like and metalloproteinase with thrombospondin-1 motifs 5, ADAM-TS 5, ADAM-TS11, ADAM-TS5, adamalysin with thrombospondin type 1 motifs-5, ADAMTS-11, ADAMTS-5, ADAMTS-5(p45), ADAMTS-5(p60), ADAMTS-5(p85), ADAMTS-5-2, ADAMTS11, ADAMTS5, ADMP-2, Agg-2, aggrecanase 2, aggrecanase-, aggrecanase-2, implantin, M12.225

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B12 ADAMTS5 endopeptidase

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Results	in table
17	Activating Compound
7	AA Sequence
12	Application
1	CAS Registry Number
20	Cloned(Commentary)
5	Crystallization (Commentary)
752	Disease/ Diagnostics
7	Expression
20	General Information
178	IC50 Value
230	Inhibitors
19	Ki Value [mM]
8	Localization
4	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
79	Organism
9	pH Optimum
6	Posttranslational Modification
3	Protein Variants
14	Purification (Commentary)
2	Reaction
9	Reaction Type
77	Reference
2	Renatured (Commentary)
70	Source Tissue
1	Specific Activity [micromol/min/mg]
89	Substrates and Products (Substrate)
6	Subunits
148	Synonyms
11	Temperature Optimum [°C]

Activating Compound

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Activating Compound on EC 3.4.24.B12 - ADAMTS5 endopeptidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

interleukin-1alpha

4 entries

-

interleukin-1beta

Bos taurus

-

increased transcription in the presence of interleukin-1beta

679600

-

NaCl

2 entries

oncostatin M

Homo sapiens

-

increased transcription in the presence of interleukin-1alpha

679600

-

retinoate

Mus musculus

-

increased transcription in the presence of retinoate

679600

retinoic acid

Mus musculus

Q9R001

-

695954

tissue necrosis factor alpha

Bos taurus

-

increased transcription in the presence of tissue necrosis factor alpha

679600

-

additional information

6 entries

-

interleukin-1alpha

Bos taurus

-

increased transcription in the presence of interleukin-1alpha

679600

-

interleukin-1alpha

Homo sapiens

-

increased transcription in the presence of interleukin-1alpha

679600

-

interleukin-1alpha

Mus musculus

-

increased transcription in the presence of interleukin-1alpha

679600

-

interleukin-1alpha

Mus musculus

Q9R001

increase of ADAMTS-5 in wild-type mice

695954

-

NaCl

Homo sapiens

-

optimal aggrecanase activity for ADAMTS-5 is detected around 200 mM NaCl

680781

NaCl

Homo sapiens

-

optimum concentration for aggrecan degradation is 200 mM

720093

additional information

Homo sapiens

-

ADAMTS5 expression is not stimulated by interleukin-1, tumor necrosis factor alpha, oncostatin M or transforming growth factor beta

679302

-

additional information

Homo sapiens

-

higher enzyme expression in degenerated intervertebral discs

695958

-

additional information

Homo sapiens

-

higher expression level in metastatic foci compared with corresponding primary tumor

698148

-

additional information

Homo sapiens

-

syndecan-4 controls the activation of ADAMTS-5 through direct interaction with the protease and through regulating mitogen-activated protein kinase (MAPK)-dependent synthesis of matrix metalloproteinase-3 (MMP-3). Syndecan-4 is crucial in regulating Mmp-3 expression by activating ERK1/2 and by targeting ADAMTS-5 to the cell surface of chondrocytes

710041

-

additional information

Mus musculus

-

ADAMTS5 expression is not stimulated by interleukin-1, tumor necrosis factor alpha, oncostatin M or transforming growth factor beta

679302

-

additional information

Mus musculus

-

little effect from interleukin-1alpha and retinoate on aggrecanase activity

680863

-