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3.4.24.85: S2P endopeptidase

This is an abbreviated version!
For detailed information about S2P endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.85

Reaction

Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site DRSR_ILL_483-/-CVLTFLCLSFNPLTSLLQWGGA, in which the membrane-spanning segment is underlined. The residues NP (bold), 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced. =

Synonyms

EcfE, Eep, HurP, I-CLiP, intramembrane-cleaving protease, MEROPS:M50, MmpA, MucP, proteinase, sterol regulatory element-binding protein, RasP, RseP, Rv2869c, S2P, S2P protease, site-1 protease, site-2 metalloprotease, site-2 protease, site-2-protease, sll0528, Slr0643, Slr1821, SPOIVFB, Sre2, SREBP cleavage activity, SREBP cysteine proteinase, SREBP proteinase, SREBP-1 proteinase, SREBP-2 proteinase, sterol regulatory element binding protein, sterol regulatory element binding protein-2 proteinase, sterol regulatory element-binding proteinase, sterol-regulated protease, Stp1, YaeL, YluC

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.85 S2P endopeptidase

Substrates Products

Substrates Products on EC 3.4.24.85 - S2P endopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
anti-sigma factor RsiV + H2O
?
show the reaction diagram
ATF-6 + H2O
?
show the reaction diagram
-
endoplasmic reticulum membrane-anchored transcription factor, sequential processing by enzyme and S1P endopeptidase. Bulky ATF6 luminal domain blocks cleavage by enzyme, cleavage by S1P endopeptidase reduces the size of the luminal domain and prepares for hydrolysis by enzyme
-
-
?
ATF6 + H2O
?
show the reaction diagram
ATF6 protein + H2O
?
show the reaction diagram
beta-casein + H2O
?
show the reaction diagram
-
-
-
?
beta-lactamase signal peptide + H2O
?
show the reaction diagram
-
cleaves within the hydrophobic core at Pro12-Phe13. Cleavage of signal peptide requires a preceding processing of preproteins by Lep
-
-
?
cAD1 pheromone + H2O
?
show the reaction diagram
-
-
-
-
?
cAD1 protein + H2O
?
show the reaction diagram
-
-
-
-
?
cCF10 protein + H2O
?
show the reaction diagram
-
-
-
-
?
CED-9 + H2O
?
show the reaction diagram
-
artificial protein substrate, Caenorhabditis elegans protein 9, homolog to human Bcl-2
-
-
?
CED-9 protein + H2O
?
show the reaction diagram
cPD1 protein + H2O
?
show the reaction diagram
-
-
-
-
?
CREBH + H2O
?
show the reaction diagram
CREBH protein + H2O
?
show the reaction diagram
-
-
-
-
?
FtsL protein + H2O
?
show the reaction diagram
-
-
-
-
?
HurR protein + H2O
?
show the reaction diagram
-
-
-
-
?
iAD1 protein + H2O
?
show the reaction diagram
-
-
-
-
?
iCF10 protein + H2O
?
show the reaction diagram
-
-
-
-
?
LivK signal peptide + H2O
?
show the reaction diagram
-
-
-
-
?
membrane-bound inactive transcription factor fragment bZIP28X1 + H2O
?
show the reaction diagram
-
transcription factor bZIP28 is cleaved within the transmembrane domain, and the N-terminal portion containing the bZIP domain is released from the membrane to translocate into the nucleus, where it activates the ER stress-responsive genes
-
-
?
membrane-bound inactive transcription factor fragment bZIP28X2 + H2O
?
show the reaction diagram
-
transcription factor bZIP28 is cleaved within the transmembrane domain, and the N-terminal portion containing the bZIP domain is released from the membrane to translocate into the nucleus, where it activates the ER stress-responsive genes
-
-
?
MSIQHFRVALIPFFAAFCLPVFA + H2O
MSIQHFRVALIP + FFAAFCLPVFA
show the reaction diagram
-
-
-
-
?
MtuA protein + H2O
?
show the reaction diagram
-
-
-
-
?
MucA protein + H2O
?
show the reaction diagram
-
-
-
-
?
N-terminus of anti-sigma factor RsiP + H2O
?
show the reaction diagram
OASIS protein + H2O
?
show the reaction diagram
-
-
-
-
?
PBP3 protein + H2O
?
show the reaction diagram
-
-
-
-
?
PodJ protein + H2O
?
show the reaction diagram
-
-
-
-
?
PodJS + H2O
?
show the reaction diagram
-
truncated form of transmembrane protein PodJ which provides the spatial cues for biogenesis of several polar organelles. Enzyme cleaves within or near the transmembrane segment of PodJS releasing it into cytoplasm for complete proteolysis
-
-
?
pro-deltaK protein + H2O
deltaK protein + N-terminal fragment of 20 amino acids of pro-deltaK protein
show the reaction diagram
-
-
-
-
?
pro-sigma K + H2O
?
show the reaction diagram
-
-
-
-
?
RseA protein + H2O
?
show the reaction diagram
-
-
-
-
?
RsiW protein + H2O
?
show the reaction diagram
-
-
-
-
?
Sre1 protein + H2O
?
show the reaction diagram
-
-
-
-
?
SREBP NH2-522 fragment + H2O
NH2-484 fragment + 38 aa fragment
show the reaction diagram
SREBP-1 + H2O
?
show the reaction diagram
SREBP-2 + H2O
?
show the reaction diagram
-
-
-
?
sterol regulatory element binding protein + H2O
?
show the reaction diagram
-
-
-
-
?
TcpP protein + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-