3.4.24.85: S2P endopeptidase

This is an abbreviated version!
For detailed information about S2P endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.85

3.4.24.85

cholesterol

srebps

triglyceride

peroxisome

lipoprotein

lipogenesis

srebp-1c

lipogenic

proliferator-activated

steatosis

adipose

obesity

acetyl-coa

high-fat

adipocyte

desaturase

hepatocytes

low-density

carnitine

obese

stearoyl-coa

amp-activated

diet-induced

site-1

proliferator

hfd-induced

cleavage-activating

nonalcoholic

adiponectin

hyperlipidemia

nafld

stearoyl

forespore

presenilins

niemann-pick

3-hydroxy-3-methylglutaryl

sigmak

gamma-secretase

membrane-embedded

atf6

rhomboid

anti-adipogenic

medicine

chrebp

acaca

synthesis

palmitoyltransferase-1

Reaction

Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site DRSR_ILL_483-/-CVLTFLCLSFNPLTSLLQWGGA, in which the membrane-spanning segment is underlined. The residues NP (bold), 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced. =

Synonyms

EcfE, Eep, HurP, I-CLiP, intramembrane-cleaving protease, MEROPS:M50, MmpA, MucP, proteinase, sterol regulatory element-binding protein, RasP, RseP, Rv2869c, S2P, S2P protease, site-1 protease, site-2 metalloprotease, site-2 protease, site-2-protease, sll0528, Slr0643, Slr1821, SPOIVFB, Sre2, SREBP cleavage activity, SREBP cysteine proteinase, SREBP proteinase, SREBP-1 proteinase, SREBP-2 proteinase, sterol regulatory element binding protein, sterol regulatory element binding protein-2 proteinase, sterol regulatory element-binding proteinase, sterol-regulated protease, Stp1, YaeL, YluC

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.85 S2P endopeptidase

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Results	in table
4	Activating Compound
1305	AA Sequence
2	Application
2	CAS Registry Number
7	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
272	Disease/ Diagnostics
3	Expression
20	General Information
25	Inhibitors
24	Localization
17	Metals/Ions
1	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
72	Organism
2	PDB ID
16	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
72	Reference
17	Source Tissue
1	Specific Activity [micromol/min/mg]
87	Substrates and Products (Substrate)
4	Subunits
164	Synonyms

Sequence

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Sequence on EC 3.4.24.85 - S2P endopeptidase

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Q0III2 pBLAST

MBTP2_BOVIN

Bos taurus

516

57214

Swiss-Prot