3.4.24.85: S2P endopeptidase

This is an abbreviated version!
For detailed information about S2P endopeptidase, go to the full flat file.

Reaction

Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site DRSR_ILL_483-/-CVLTFLCLSFNPLTSLLQWGGA, in which the membrane-spanning segment is underlined. The residues NP (bold), 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced. =

Synonyms

EcfE, Eep, HurP, I-CLiP, intramembrane-cleaving protease, MEROPS:M50, MmpA, MucP, proteinase, sterol regulatory element-binding protein, RasP, RseP, Rv2869c, S2P, S2P protease, site-1 protease, site-2 metalloprotease, site-2 protease, site-2-protease, sll0528, Slr0643, Slr1821, SPOIVFB, Sre2, SREBP cleavage activity, SREBP cysteine proteinase, SREBP proteinase, SREBP-1 proteinase, SREBP-2 proteinase, sterol regulatory element binding protein, sterol regulatory element binding protein-2 proteinase, sterol regulatory element-binding proteinase, sterol-regulated protease, Stp1, YaeL, YluC

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.85 S2P endopeptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
4	Activating Compound
1305	AA Sequence
2	Application
2	CAS Registry Number
7	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
272	Disease/ Diagnostics
3	Expression
20	General Information
25	Inhibitors
24	Localization
17	Metals/Ions
1	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
72	Organism
2	PDB ID
16	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
72	Reference
17	Source Tissue
1	Specific Activity [micromol/min/mg]
87	Substrates and Products (Substrate)
4	Subunits
164	Synonyms

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 3.4.24.85 - S2P endopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

-

nelfinavir and its analogs inhibit castration-resistant prostate cancer proliferation by blocking regulated intramembrane proteolysis through suppression of site-2 protease cleavage activity. This leads to accumulation of precursors of sterol regulatory element-binding protein SREBP-1 and activating transcription factor ATF6, and development of insufficient reserves of their transcriptionally-active forms

733824

synthesis

Homo sapiens

O43462

in absence of cholesterol, SREBP double cleavage leads to activation of transcription of genes encoding multiple enzymes of the cholesterol biosynthetic pathway

644080