3.4.24.81: ADAM10 endopeptidase

This is an abbreviated version!
For detailed information about ADAM10 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.81

3.4.24.81

alzheimer

adam17

amyloid

ectodomain

sheddase

alpha-secretase

endothelial

metalloproteases

neuroprotective

plaque

amyloidogenic

non-amyloidogenic

tnf

sh-sy5y

synaptic

secretase

membrane-anchored

tetraspanins

gamma-secretase

n-cadherin

presenilins

notch1

intramembrane

abeta

cxcl16

prpc

prion

amyloid-beta

prodomains

psen1

beta-secretase

sappalpha

hb-egf

beta-site

trans-signaling

amphiregulin

fractalkine

meprin

disintegrin-like

adam17-mediated

app-cleaving

betacellulin

nicastrin

timp-3

molecular biology

anti-amyloidogenic

medicine

srage

notch-dependent

ad-like

juxtamembrane

bace-1

Reaction

endopeptidase of broad specificity =

Synonyms

a disintegrin and metalloprotease 10, a disintegrin and metalloproteinase 10, a disintegrin and metalloproteinase-10, a-disintegrin-and-metalloprotease 10, AD10, ADAM 10, ADAM-10, ADAM10, CD156c, CD23 metalloprotease, HsT18717, kuz, kuzbanian, Kuzbanian protein, MADM, mammalian disintegrin-metalloprotease, metalloproteinase 10, metalloproteinase ADAM10, metalloproteinase Kuzbanian, metalloproteinase MADM, metalloproteinase-disintegrin, myelin-associated disintegrin metalloproteinase, notch proteinase, transmembrane metzinkin-protease of the a disintegrin and metalloproteinase family-10

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.81 ADAM10 endopeptidase

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Results	in table
58	Activating Compound
1745	AA Sequence
19	Application
1	CAS Registry Number
14	Cloned(Commentary)
1	Crystallization (Commentary)
2223	Disease/ Diagnostics
8	Expression
57	General Information
5	IC50 Value
92	Inhibitors
2	kcat/KM [mM/s]
4	Ki Value [mM]
2	KM Value [mM]
33	Localization
7	Metals/Ions
15	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
128	Organism
8	PDB ID
1	pH Optimum
1	pI Value
12	Posttranslational Modification
31	Protein Variants
6	Purification (Commentary)
1	Reaction
2	Reaction Type
125	Reference
175	Source Tissue
2	Specific Activity [micromol/min/mg]
161	Substrates and Products (Substrate)
8	Subunits
138	Synonyms
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Reaction

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Reaction on EC 3.4.24.81 - ADAM10 endopeptidase

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endopeptidase of broad specificity