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3.4.24.81: ADAM10 endopeptidase

This is an abbreviated version!
For detailed information about ADAM10 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.81

Reaction

endopeptidase of broad specificity =

Synonyms

a disintegrin and metalloprotease 10, a disintegrin and metalloproteinase 10, a disintegrin and metalloproteinase-10, a-disintegrin-and-metalloprotease 10, AD10, ADAM 10, ADAM-10, ADAM10, CD156c, CD23 metalloprotease, HsT18717, kuz, kuzbanian, Kuzbanian protein, MADM, mammalian disintegrin-metalloprotease, metalloproteinase 10, metalloproteinase ADAM10, metalloproteinase Kuzbanian, metalloproteinase MADM, metalloproteinase-disintegrin, myelin-associated disintegrin metalloproteinase, notch proteinase, transmembrane metzinkin-protease of the a disintegrin and metalloproteinase family-10

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.81 ADAM10 endopeptidase

Activating Compound

Activating Compound on EC 3.4.24.81 - ADAM10 endopeptidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4-aminophenyl)mercuric acetate
-
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5-hydroxytryptamine receptor
-
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5alpha-dihydrotestosterone
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10 nM, in the presence of 10 or 50 ng/ml insulin-like growth factor, 1.8fold upregulation of the 100-kDa proform and 3 to 4 fold stimulation of the active 60-kDa form
A23187
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calcium ionophore
acetyl-L-carnitine
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alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate
-
-
bombesin receptor
-
-
cryptotanshinone
-
donepezil
-
because donepezil-treated cells show an increase in the metabolic active form of ADAM 10, this suggests that donepezil may cause a direct increase in the level of ADAM 10 in cellular membranes
donezipil
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Epidermal growth factor
-
50 ng/ml, 2fold stimulation of 100-kDa proform and 3fold stimulation of 60-kDa form
epigallocatechin-3-gallate
-
FLZ
synthetic analogue of natural squamosamide
formononentin
-
G-protein-coupled purinergic receptor
-
-
gintonin
-
-
glucagon-like peptide-1 receptor
-
-
Insulin
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0.001 mM, stimulates the cleavage of the extracellular domain of Klotho
-
insulin-like growth factor I
-
10 ng/ml or 50 ng/ml, in the presence of 10 nM 5alpha-dihydrotestosterone, 1.8fold upregulation of the 100-kDa proform and 3 to 4fold stimulation of the active 60-kDa form
-
interleukin-1alpha
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2 ng/ml stimulates ADAM-10 level 2.1 fold after 16h treatment
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ion channel purinergic receptor
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-
ionomycin
metallothionein III
-
-
nardilysin
-
-
phorbol 12-myristate 13-acetate
-
-
phorbol myristate acetate
-
100 nM, induces the expression of the highly processed form of ADAM10
phorbol-12 myristate 13-acetate
pituitary adenylate cyclase-activating polypeptide receptor
-
-
S100A7
-
expression of exogenous S100A7, a biomarker protein for alzheimer’s disease known to be involved in immune responses, in primary cortico-hippocampal neuron cultures derived from Tg2576 transgenic mice embryos inhibits the generation of beta-amyloid (Abeta)1-42 and Abeta1-40 peptides, coincidental with a selective promotion of non-amyloidogenic alpha-secretase activity via promotion of ADAM10. A selective expression of human S100A7, in the brain of transgenic mice results in significant promotion of alpha-secretase activity
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staurosporine
synapse-associated protein 97
-
-
tetraspanin
-
several anti-tetraspanin mAbs (CD9, CD81, CD82) increase epidermal growth factor and/or TNF-alpha secretion through a mechanism dependent on ADAM10. The effect of anti-tetraspanin mAb on TNF-alpha release is rapid, not relayed by intercellular signaling, and depends on an intact MEK/Erk1/2 pathway. It is also associated with a concentration of ADAM10 in tetraspanin-containing patches. A large fraction of ADAM10 associates with several tetraspanins
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tetraspanin 10
-
-
tetraspanin 12
-
tetraspanin 14
-
-
tetraspanin 15
-
-
tetraspanin 17
-
-
tetraspanin 27
-
-
tetraspanin 28
-
-
tetraspanin 29
-
-
tetraspanin 33
-
-
tetraspanin 5
-
-
thyrotropin
increases dose dependently thyrotropin receptor ectodomain cleavage
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additional information
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