3.4.24.81: ADAM10 endopeptidase
This is an abbreviated version!
For detailed information about ADAM10 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.81
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3.4.24.81
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alzheimer
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adam17
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amyloid
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ectodomain
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sheddase
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alpha-secretase
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endothelial
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metalloproteases
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neuroprotective
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plaque
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amyloidogenic
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non-amyloidogenic
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tnf
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sh-sy5y
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synaptic
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secretase
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membrane-anchored
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tetraspanins
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gamma-secretase
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n-cadherin
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presenilins
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notch1
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intramembrane
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abeta
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cxcl16
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prpc
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prion
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amyloid-beta
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prodomains
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psen1
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beta-secretase
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sappalpha
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hb-egf
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beta-site
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trans-signaling
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amphiregulin
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fractalkine
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meprin
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disintegrin-like
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adam17-mediated
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app-cleaving
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betacellulin
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nicastrin
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timp-3
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molecular biology
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anti-amyloidogenic
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medicine
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srage
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notch-dependent
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ad-like
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juxtamembrane
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bace-1
- 3.4.24.81
- alzheimer
- adam17
-
amyloid
- ectodomain
- sheddase
- alpha-secretase
- endothelial
- metalloproteases
-
neuroprotective
- plaque
-
amyloidogenic
-
non-amyloidogenic
- tnf
-
sh-sy5y
- synaptic
-
secretase
-
membrane-anchored
- tetraspanins
- gamma-secretase
- n-cadherin
-
presenilins
- notch1
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intramembrane
- abeta
- cxcl16
- prpc
- prion
- amyloid-beta
- prodomains
- psen1
- beta-secretase
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sappalpha
- hb-egf
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beta-site
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trans-signaling
- amphiregulin
- fractalkine
- meprin
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disintegrin-like
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adam17-mediated
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app-cleaving
- betacellulin
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nicastrin
- timp-3
- molecular biology
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anti-amyloidogenic
- medicine
-
srage
-
notch-dependent
-
ad-like
-
juxtamembrane
- bace-1
Reaction
endopeptidase of broad specificity =
Synonyms
a disintegrin and metalloprotease 10, a disintegrin and metalloproteinase 10, a disintegrin and metalloproteinase-10, a-disintegrin-and-metalloprotease 10, AD10, ADAM 10, ADAM-10, ADAM10, CD156c, CD23 metalloprotease, HsT18717, kuz, kuzbanian, Kuzbanian protein, MADM, mammalian disintegrin-metalloprotease, metalloproteinase 10, metalloproteinase ADAM10, metalloproteinase Kuzbanian, metalloproteinase MADM, metalloproteinase-disintegrin, myelin-associated disintegrin metalloproteinase, notch proteinase, transmembrane metzinkin-protease of the a disintegrin and metalloproteinase family-10
ECTree
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Activating Compound
Activating Compound on EC 3.4.24.81 - ADAM10 endopeptidase
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5alpha-dihydrotestosterone
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10 nM, in the presence of 10 or 50 ng/ml insulin-like growth factor, 1.8fold upregulation of the 100-kDa proform and 3 to 4 fold stimulation of the active 60-kDa form
donepezil
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because donepezil-treated cells show an increase in the metabolic active form of ADAM 10, this suggests that donepezil may cause a direct increase in the level of ADAM 10 in cellular membranes
Epidermal growth factor
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50 ng/ml, 2fold stimulation of 100-kDa proform and 3fold stimulation of 60-kDa form
Insulin
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0.001 mM, stimulates the cleavage of the extracellular domain of Klotho
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insulin-like growth factor I
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10 ng/ml or 50 ng/ml, in the presence of 10 nM 5alpha-dihydrotestosterone, 1.8fold upregulation of the 100-kDa proform and 3 to 4fold stimulation of the active 60-kDa form
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interleukin-1alpha
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2 ng/ml stimulates ADAM-10 level 2.1 fold after 16h treatment
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phorbol myristate acetate
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100 nM, induces the expression of the highly processed form of ADAM10
S100A7
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expression of exogenous S100A7, a biomarker protein for alzheimers disease known to be involved in immune responses, in primary cortico-hippocampal neuron cultures derived from Tg2576 transgenic mice embryos inhibits the generation of beta-amyloid (Abeta)1-42 and Abeta1-40 peptides, coincidental with a selective promotion of non-amyloidogenic alpha-secretase activity via promotion of ADAM10. A selective expression of human S100A7, in the brain of transgenic mice results in significant promotion of alpha-secretase activity
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tetraspanin
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several anti-tetraspanin mAbs (CD9, CD81, CD82) increase epidermal growth factor and/or TNF-alpha secretion through a mechanism dependent on ADAM10. The effect of anti-tetraspanin mAb on TNF-alpha release is rapid, not relayed by intercellular signaling, and depends on an intact MEK/Erk1/2 pathway. It is also associated with a concentration of ADAM10 in tetraspanin-containing patches. A large fraction of ADAM10 associates with several tetraspanins
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thyrotropin
increases dose dependently thyrotropin receptor ectodomain cleavage
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0.005 mM, strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment
ionomycin
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strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment
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strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment
staurosporine
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strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment
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cells overexpressing ADAM10 are not responsive to phorbol ester-induced cleavage, indicating constitutive activity and not Protein kinase C induced activity
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additional information
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4-aminophenylmercuric acetate does not stimulate the shedding of beta-amyloid precursor protein
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additional information
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no activation by 0.1 M phorbol 12-myristate 13-acetate
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additional information
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no increase in the amount of gamma-Protocadherin C3 25-kDa C-terminal fragment was observed when the ADAM10 inhibitor GI254023X is added to the cells prior to PMA stimulation
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