3.4.24.77: snapalysin
This is an abbreviated version!
For detailed information about snapalysin, go to the full flat file.
Word Map on EC 3.4.24.77
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3.4.24.77
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disintegrin
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collagen
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mmp-2
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thrombospondin
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endothelial
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timp-1
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necrosis
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metastasis
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cartilage
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collagenase
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venom
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zymography
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angiogenesis
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gelatinase
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fibrosis
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platelet
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chondrocytes
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gelatin
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osteoarthritis
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thrombotic
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adamts13
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willebrand
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snake
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proteinases
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articular
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plasminogen
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ectodomain
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proteoglycans
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basement
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adam17
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thrombocytopenic
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aggrecan
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purpura
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ttp
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1,10-phenanthroline
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synovial
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mt1-mmp
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stromelysin
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zinc-dependent
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bothrops
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matrix-degrading
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phosphoramidon
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membrane-type
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gelatinolytic
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microangiopathy
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collagenolytic
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papp-a
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bonts
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hb-egf
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degradation
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botulism
- 3.4.24.77
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disintegrin
- collagen
- mmp-2
- thrombospondin
- endothelial
- timp-1
- necrosis
- metastasis
- cartilage
- collagenase
- venom
-
zymography
- angiogenesis
- gelatinase
- fibrosis
- platelet
- chondrocytes
- gelatin
- osteoarthritis
-
thrombotic
- adamts13
- willebrand
- snake
- proteinases
-
articular
- plasminogen
- ectodomain
- proteoglycans
-
basement
- adam17
-
thrombocytopenic
- aggrecan
- purpura
- ttp
- 1,10-phenanthroline
- synovial
- mt1-mmp
- stromelysin
-
zinc-dependent
- bothrops
-
matrix-degrading
- phosphoramidon
-
membrane-type
-
gelatinolytic
- microangiopathy
-
collagenolytic
- papp-a
-
bonts
- hb-egf
- degradation
- botulism
Reaction
hydrolyses proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides =
Synonyms
acidolysin, ATNase, extracellular metalloendopeptidase, Extracellular metalloprotease, extracellular proteinase, gene AFG3 metalloproteinase, metalloendopeptidase, metalloendoprotease, metalloprotease, metalloproteinase, N-(2,4)-dinitrophenylpeptidase, proteinase, metallo-, ScNP, small neutral protease, Snapalysin, SnpA gene product, SSMP, thermophilic protease
ECTree
3.4.24.77 snapalysinAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.24.77 - snapalysin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Arg-Pro-Pro-Gly-Phe-Ser-Pro + H2O
Arg-Pro-Pro-Gly + Phe-Ser-Pro
-
-
-
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg
-
-
-
-
?
furylacryloyl-Met-Leu-Phe-Lys + H2O
furylacryloyl-Met-Leu + Phe-Lys
-
-
-
-
?
Met-Gly-Trp-Met-Asp-Phe-NH2 + H2O
Met-Gly-Trp-Met-Asp + Phe-NH2
-
-
-
-
?
N-benzyloxycarbonyl-Glu-Phe + H2O
N-benzyloxycarbonyl-Glu + Phe
-
-
-
-
?
N-benzyloxycarbonyl-Gly-Phe + H2O
N-benzyloxycarbonyl-Gly + Phe
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Asp-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Ile-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Lys-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Pro-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Tyr-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Arg-Asp-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Arg-Ile-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Arg-Lys-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Arg-Pro-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Arg-Tyr-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Glu-Asp-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Glu-Ile-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Glu-Lys-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Glu-Pro-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Glu-Tyr-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Phe-Asp-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Phe-Ile-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Phe-Lys-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Phe-Pro-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Phe-Tyr-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Val-Asp-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Val-Ile-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Val-Lys-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Val-Pro-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Val-Tyr-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
Insulin B-chain + H2O
?
-
high specificity for aromatic residues such as Phe and Tyr
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Asp-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Asp-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Ile-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Ile-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Lys-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Lys-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Pro-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Pro-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Tyr-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
N-[2-(N-methylamino)benzoyl]-2,3-diaminopropionic acid-Gly-Ala-Tyr-Phe-Ala-Phe-Pro-Lys(2,4-dinitrophenyl)-D-Arg-D-Arg + H2O
?
-
-
-
-
?
additional information
?
-
-
no hydrolysis of N-benzyloxycarbonyl-Gly-Tyr
-
-
?
additional information
?
-
-
no hydrolysis of succinyl-Ala-Ala-Pro-Phe-p-nitroanilide, benzoyl-Arg-p-nitroanilide, N-benzyloxycarbonyl-Gly-Gly-Leu-p-nitroanilide
-
-
?
