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3.4.24.77: snapalysin

This is an abbreviated version!
For detailed information about snapalysin, go to the full flat file.

Word Map on EC 3.4.24.77

Reaction

hydrolyses proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides =

Synonyms

acidolysin, ATNase, extracellular metalloendopeptidase, Extracellular metalloprotease, extracellular proteinase, gene AFG3 metalloproteinase, metalloendopeptidase, metalloendoprotease, metalloprotease, metalloproteinase, N-(2,4)-dinitrophenylpeptidase, proteinase, metallo-, ScNP, small neutral protease, Snapalysin, SnpA gene product, SSMP, thermophilic protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.77 snapalysin

Inhibitors

Inhibitors on EC 3.4.24.77 - snapalysin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
antipain dihydrochloride
-
0.074 mM, 94.9% residual proteolytic activity
Ca2+
-
more than 2 mM
chymostatin
-
0.1 mM, 91.7% residual proteolytic activity
Cu2+
-
10 mM, 46% inhibition
diisopropyl fluorophosphate
-
-
FeSO4
-
2 mM, activity decreases to less than 20% of the maximum
iodoacetamide
-
-
N-bromosuccinimide
-
1 mM, 97% inhibition
N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]leucine
-
0.13 mM, 96.1% residual proteolytic activity
NiSO4
-
2 mM, activity decreases to less than 20% of the maximum
pefabloc
-
1 mM, 82.3% residual proteolytic activity
Phenanthroline
-
-
phenyl-methyl-sulfonyl-fluoride
-
-
phosphoramidon
-
0.6 mM, no residual proteolytic activity
thiorphan
-
0.001 mM and 0.0001 mM, 35% and 47% inhibition, respectively
Zn2+
-
0.01 mM
ZnSO4
-
2 mM, activity decreases to less than 20% of the maximum
additional information
-
no inhibitory effect of phenyl-methyl-sulfonyl-fluoride and p-chlormercuribenzoate
-