3.4.24.76: flavastacin
This is an abbreviated version!
For detailed information about flavastacin, go to the full flat file.
Reaction
Hydrolyses polypeptides on the amino-side of Asp in -Xaa-/-Asp-. Acts very slowly on -Xaa-/-Glu =
Synonyms
AspN, More, P40
ECTree
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Substrates Products on EC 3.4.24.76 - flavastacin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dansyl-Leu-(biantennary oligosaccharide)Asn-Asp-Ser-Arg-Val + H2O
dansyl-Leu-(biantennary oligosaccharide)Asn + Asp-Ser-Arg-Val
-
-
-
?
furylacryloyl-Leu-Ala-Asp-Ala-Ala-NH2 + H2O
furylacryloyl-Leu-Ala + Asp-Ala-Ala-NH2
-
-
-
-
?
N-glycosylated asparagine in glycoproteine + H2O
?
tryptic fragments. The enzyme shows unique cleavage specificity towards the C-terminus of N-glycosylated asparagine residues (N156)
-
-
?
TAGWNIPMGLLFNQTGSCK + H2O
TAGWNIPMGLLFN + QTGSCK
-
-
-
?
TAGWNVPIGTLRPFLNWTGPPEPIEAAVAR + H2O
TAGWNVPIGTLRPFLN + WTGPPEPIEAAVAR
-
-
-
?
furylacryloyl-Leu-Ala-Asp-Ala-Ser-NH2 + H2O
furylacryloyl-Leu-Ala + Asp-Ser-Ala-NH2
-
-
-
?
furylacryloyl-Leu-Ala-Asp-Ala-Ser-NH2 + H2O
furylacryloyl-Leu-Ala + Asp-Ser-Ala-NH2
-
hydrolyzes peptides on the N-terminal side of aspartic acid
-
-
?
additional information
?
-
-
aspargine and glutamine analogs not hydrolyzed, at high enzyme concentrations slow cleavage of the glutamic acid analog
-
-
?
additional information
?
-
the enzyme works only on peptides smaller than 50 amino acids and has no specificity for the N-terminus of aspartic acid
-
-
?
