3.4.24.75: lysostaphin
This is an abbreviated version!
For detailed information about lysostaphin, go to the full flat file.
Word Map on EC 3.4.24.75
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3.4.24.75
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staphylococci
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methicillin-resistant
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vancomycin
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simulans
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bactericidal
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pentaglycine
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bacteriolytic
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methicillin
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epidermidis
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mastitis
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antistaphylococcal
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cross-bridge
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bacteriocins
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staphylolyticus
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medicine
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autolysins
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oxacillin
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endolysins
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interpeptide
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teichoic
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biovar
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intramammary
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coagulase-negative
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muropeptide
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teicoplanin
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methicillin-sensitive
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cowan
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micrococci
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murein
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haemolyticus
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coagulase
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daptomycin
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mutanolysine
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diagnostics
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pharmacology
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food industry
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analysis
- 3.4.24.75
-
staphylococci
-
methicillin-resistant
- vancomycin
- simulans
-
bactericidal
- pentaglycine
-
bacteriolytic
- methicillin
- epidermidis
- mastitis
-
antistaphylococcal
-
cross-bridge
-
bacteriocins
- staphylolyticus
- medicine
- autolysins
- oxacillin
- endolysins
-
interpeptide
-
teichoic
-
biovar
-
intramammary
-
coagulase-negative
-
muropeptide
- teicoplanin
-
methicillin-sensitive
-
cowan
-
micrococci
- murein
- haemolyticus
- coagulase
-
daptomycin
-
mutanolysine
- diagnostics
- pharmacology
- food industry
- analysis
Reaction
Hydrolysis of the -Gly-/-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans =
Synonyms
ALE-1, BSYX-L210, Glycyl-glycine endopeptidase, Glycylglycine endopeptidase, Lspn, Lss, Lst, LYS, lysostaphin, Lysostaphin endopeptidase, LytU, More, peptidoglycan endopeptidase, r-Lys, r-lysostaphin, sa0205, SH3b, Staphylococcus aureus-specific cell wall endopeptidase lysostaphin
ECTree
3.4.24.75 lysostaphinAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.4.24.75 - lysostaphin
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
Co2+
10 mM, 30% decrease of activity of enzyme produced with pET vector system and 20% decrease of activity of enzyme produced with pBAD vector system
ethanolamine
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inhibits enzyme binding to the cell surface, leading to low enzyme activity, despite retention of its secondary structure. At pH 10.5 (but not at pH 7.5), methanolamine strongly deactivates the enzyme in a concentration-dependent manner
Ni2+
2 mM, 60% decrease of activity of enzyme produced with pET vector system and 20% decrease of activity of enzyme produced with pBAD vector system
Zn2+
partial inhibition of enzyme activity is observed in the excess of zinc
additional information
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not inhibitory is trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane, i.e. E-64
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additional information
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binding of elastin to lysostaphin is not affected by exogenously added zinc, suggesting that zinc interferes directly with the catalytic activity of the enzyme
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additional information
no inhibitory effect of EDTA and 2 mM Co2+
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additional information
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no inhibitory effect of EDTA and 2 mM Co2+
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additional information
the bacteriolytic activity of the enzyme is reduced to about 60% in the presence of 150 mM NaCl which causes contractions of bacterial peptidoglycan substrate
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additional information
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the bacteriolytic activity of the enzyme is reduced to about 60% in the presence of 150 mM NaCl which causes contractions of bacterial peptidoglycan substrate
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